Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer

Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process. In this study, freshly isolated triple-negative breast cancer biopsied cells obtained from consenting patients were subjected to flow...

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Detalles Bibliográficos
Autores principales: Ma, Yanfei, Li, Yanghong, Guo, Pengwei, Zhao, Jingjie, Qin, Qiang, Wang, Jiajia, Liang, Zhengfang, Wei, Dalong, Wang, Zechen, Shen, Jiajia, He, Siyuan, Tang, Qianli, Lu, Guanming, Shi, Guiling, Meng, Lingzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898858/
https://www.ncbi.nlm.nih.gov/pubmed/35265720
http://dx.doi.org/10.1155/2022/5412007
Descripción
Sumario:Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process. In this study, freshly isolated triple-negative breast cancer biopsied cells obtained from consenting patients were subjected to flow cytometry and bioinformatic analysis to identify three endothelial cell subclusters: EC (ATP1B3), EC (HSPA1B), and EC (KRT7) in the tumor microenvironment. These endothelial cell subclusters exhibited distinguishing biological features. Based on differentially expressed genes derived from the subclusters, gene set enrichment analysis showed that EC (ATP1B3) and EC (HSPA1B) contribute to the process of metastasis, for example, in fibrosarcoma and anaplastic carcinoma. In this study, we identified the heterogeneity of endothelial cells in the human breast cancer and have provided insights into its role in metastasis.

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