Cargando…

Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations

The control of strongylid infections has become challenging globally for equine practitioners due to the development of anthelmintic resistance. Comprehensive information on anthelmintic resistance in the Czech Republic, however, is still lacking. This study monitored the current efficacy of fenbend...

Descripción completa

Detalles Bibliográficos
Autores principales: Nápravníková, Jana, Várady, Marián, Vadlejch, Jaroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899116/
https://www.ncbi.nlm.nih.gov/pubmed/35265696
http://dx.doi.org/10.3389/fvets.2022.833204
_version_ 1784663834966884352
author Nápravníková, Jana
Várady, Marián
Vadlejch, Jaroslav
author_facet Nápravníková, Jana
Várady, Marián
Vadlejch, Jaroslav
author_sort Nápravníková, Jana
collection PubMed
description The control of strongylid infections has become challenging globally for equine practitioners due to the development of anthelmintic resistance. Comprehensive information on anthelmintic resistance in the Czech Republic, however, is still lacking. This study monitored the current efficacy of fenbendazole, pyrantel embonate, ivermectin and moxidectin. Forty-eight of 71 operations met the criteria (≥6 horses with ≥200 eggs per gram), with 969 fecal egg count reduction tests performed. Anthelmintic resistance was evaluated on an operation level based on fecal egg count reduction (FECR) and the lower limit of the 95% credible interval (LLCI) using Bayesian hierarchical models. General anthelmintic efficacy across all operations was assessed by posterior FECRs and the occurrence of sub-zero efficacies. Ivermectin and moxidectin demonstrated excellent efficacy (FECR 99.8–100%; 99.4–100 LLCI) in 45 and 23 operations, respectively, pyrantel embonate demonstrated sufficient efficacy in 15 operations and resistance was suspected in seven operations (FECR 88.1–99.1%; 72.5–98.5 LLCI). Fenbendazole, however, was not effective in a single operation (FECR 19.1–77.8%; 8.1–50.1 LLCI) out of 18. Fenbendazole had the highest probability of sub-zero efficacy (29.1%), i.e., post-treatment fecal egg counts exceeded the pre-treatment counts. Our data indicate an increase in the development of anthelmintic resistance, resulting in total failure of fenbendazole and a reduced efficacy of pyrantel embonate. Introducing advanced approaches of parasite control in the Czech Republic to slow the spread of anthelmintic resistance is thus needed.
format Online
Article
Text
id pubmed-8899116
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88991162022-03-08 Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations Nápravníková, Jana Várady, Marián Vadlejch, Jaroslav Front Vet Sci Veterinary Science The control of strongylid infections has become challenging globally for equine practitioners due to the development of anthelmintic resistance. Comprehensive information on anthelmintic resistance in the Czech Republic, however, is still lacking. This study monitored the current efficacy of fenbendazole, pyrantel embonate, ivermectin and moxidectin. Forty-eight of 71 operations met the criteria (≥6 horses with ≥200 eggs per gram), with 969 fecal egg count reduction tests performed. Anthelmintic resistance was evaluated on an operation level based on fecal egg count reduction (FECR) and the lower limit of the 95% credible interval (LLCI) using Bayesian hierarchical models. General anthelmintic efficacy across all operations was assessed by posterior FECRs and the occurrence of sub-zero efficacies. Ivermectin and moxidectin demonstrated excellent efficacy (FECR 99.8–100%; 99.4–100 LLCI) in 45 and 23 operations, respectively, pyrantel embonate demonstrated sufficient efficacy in 15 operations and resistance was suspected in seven operations (FECR 88.1–99.1%; 72.5–98.5 LLCI). Fenbendazole, however, was not effective in a single operation (FECR 19.1–77.8%; 8.1–50.1 LLCI) out of 18. Fenbendazole had the highest probability of sub-zero efficacy (29.1%), i.e., post-treatment fecal egg counts exceeded the pre-treatment counts. Our data indicate an increase in the development of anthelmintic resistance, resulting in total failure of fenbendazole and a reduced efficacy of pyrantel embonate. Introducing advanced approaches of parasite control in the Czech Republic to slow the spread of anthelmintic resistance is thus needed. Frontiers Media S.A. 2022-02-21 /pmc/articles/PMC8899116/ /pubmed/35265696 http://dx.doi.org/10.3389/fvets.2022.833204 Text en Copyright © 2022 Nápravníková, Várady and Vadlejch. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Nápravníková, Jana
Várady, Marián
Vadlejch, Jaroslav
Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations
title Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations
title_full Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations
title_fullStr Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations
title_full_unstemmed Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations
title_short Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations
title_sort total failure of fenbendazole to control strongylid infections in czech horse operations
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899116/
https://www.ncbi.nlm.nih.gov/pubmed/35265696
http://dx.doi.org/10.3389/fvets.2022.833204
work_keys_str_mv AT napravnikovajana totalfailureoffenbendazoletocontrolstrongylidinfectionsinczechhorseoperations
AT varadymarian totalfailureoffenbendazoletocontrolstrongylidinfectionsinczechhorseoperations
AT vadlejchjaroslav totalfailureoffenbendazoletocontrolstrongylidinfectionsinczechhorseoperations