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Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease

Parkinson's disease (PD) is caused by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Although PD pathogenesis is not fully understood, studies implicate perturbations in gene regulation, mitochondrial function, and neuronal activity. MicroRNAs (miRs) are small gene regulato...

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Detalles Bibliográficos
Autores principales: Stein, Colleen S., McLendon, Jared M., Witmer, Nathan H., Boudreau, Ryan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899134/
https://www.ncbi.nlm.nih.gov/pubmed/35280925
http://dx.doi.org/10.1016/j.omtn.2022.02.007