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Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis
Sepsis is an aberrant systemic inflammatory response mediated by the acute activation of the innate immune system. Neutrophils are important contributors to the innate immune response that controls the infection, but harbour the risk of collateral tissue damage such as thrombosis and organ dysfuncti...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899167/ https://www.ncbi.nlm.nih.gov/pubmed/35174610 http://dx.doi.org/10.1111/jcmm.17240 |
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author | Huang, Susie Shih Yin Rinchai, Darawan Toufiq, Mohammed Kabeer, Basirudeen Syed Ahamed Roelands, Jessica Hendrickx, Wouter Boughorbel, Sabri Bedognetti, Davide Van Panhuys, Nicholas Chaussabel, Damien Garand, Mathieu |
author_facet | Huang, Susie Shih Yin Rinchai, Darawan Toufiq, Mohammed Kabeer, Basirudeen Syed Ahamed Roelands, Jessica Hendrickx, Wouter Boughorbel, Sabri Bedognetti, Davide Van Panhuys, Nicholas Chaussabel, Damien Garand, Mathieu |
author_sort | Huang, Susie Shih Yin |
collection | PubMed |
description | Sepsis is an aberrant systemic inflammatory response mediated by the acute activation of the innate immune system. Neutrophils are important contributors to the innate immune response that controls the infection, but harbour the risk of collateral tissue damage such as thrombosis and organ dysfunction. A better understanding of the modulations of cellular processes in neutrophils and other blood cells during sepsis is needed and can be initiated via transcriptomic profile investigations. To that point, the growing repertoire of publicly accessible transcriptomic datasets serves as a valuable resource for discovering and/or assessing the robustness of biomarkers. We employed systematic literature mining, reductionist approach to gene expression profile and empirical in vitro work to highlight the role of a Nudix hydrolase family member, NUDT16, in sepsis. The relevance and implication of the expression of NUDT16 under septic conditions and the putative functional roles of this enzyme are discussed. |
format | Online Article Text |
id | pubmed-8899167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88991672022-03-11 Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis Huang, Susie Shih Yin Rinchai, Darawan Toufiq, Mohammed Kabeer, Basirudeen Syed Ahamed Roelands, Jessica Hendrickx, Wouter Boughorbel, Sabri Bedognetti, Davide Van Panhuys, Nicholas Chaussabel, Damien Garand, Mathieu J Cell Mol Med Short Communications Sepsis is an aberrant systemic inflammatory response mediated by the acute activation of the innate immune system. Neutrophils are important contributors to the innate immune response that controls the infection, but harbour the risk of collateral tissue damage such as thrombosis and organ dysfunction. A better understanding of the modulations of cellular processes in neutrophils and other blood cells during sepsis is needed and can be initiated via transcriptomic profile investigations. To that point, the growing repertoire of publicly accessible transcriptomic datasets serves as a valuable resource for discovering and/or assessing the robustness of biomarkers. We employed systematic literature mining, reductionist approach to gene expression profile and empirical in vitro work to highlight the role of a Nudix hydrolase family member, NUDT16, in sepsis. The relevance and implication of the expression of NUDT16 under septic conditions and the putative functional roles of this enzyme are discussed. John Wiley and Sons Inc. 2022-02-17 2022-03 /pmc/articles/PMC8899167/ /pubmed/35174610 http://dx.doi.org/10.1111/jcmm.17240 Text en © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communications Huang, Susie Shih Yin Rinchai, Darawan Toufiq, Mohammed Kabeer, Basirudeen Syed Ahamed Roelands, Jessica Hendrickx, Wouter Boughorbel, Sabri Bedognetti, Davide Van Panhuys, Nicholas Chaussabel, Damien Garand, Mathieu Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
title | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
title_full | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
title_fullStr | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
title_full_unstemmed | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
title_short | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
title_sort | transcriptomic profile investigations highlight a putative role for nudt16 in sepsis |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899167/ https://www.ncbi.nlm.nih.gov/pubmed/35174610 http://dx.doi.org/10.1111/jcmm.17240 |
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