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A radiologist’s guide to novel anticancer therapies in the era of precision medicine

Novel anticancer agents have replaced conventional chemotherapy as first line agents for many cancers, with continued new and expanding indications. Small molecule inhibitors act on cell surface or intracellular targets and prevent the downstream signaling that would otherwise permit tumor growth an...

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Detalles Bibliográficos
Autores principales: Khader, Ali, Bokhari, Rozan, Hakimelahi, Reza, Scheirey, Christopher, Afnan, Jalil, Braschi-Amirfarzan, Marta, Thomas, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899228/
https://www.ncbi.nlm.nih.gov/pubmed/35265736
http://dx.doi.org/10.1016/j.ejro.2022.100406
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author Khader, Ali
Bokhari, Rozan
Hakimelahi, Reza
Scheirey, Christopher
Afnan, Jalil
Braschi-Amirfarzan, Marta
Thomas, Richard
author_facet Khader, Ali
Bokhari, Rozan
Hakimelahi, Reza
Scheirey, Christopher
Afnan, Jalil
Braschi-Amirfarzan, Marta
Thomas, Richard
author_sort Khader, Ali
collection PubMed
description Novel anticancer agents have replaced conventional chemotherapy as first line agents for many cancers, with continued new and expanding indications. Small molecule inhibitors act on cell surface or intracellular targets and prevent the downstream signaling that would otherwise permit tumor growth and spread. Anticancer antibodies can be directed against growth factors or may be immunotherapeutic agents. The latter act by inhibiting mechanisms that cancer cells use to evade the immune system. Hormonal agents act by decreasing levels of hormones that are necessary for the growth of certain cancer cells. Cancer therapy protocols often include novel anticancer agents and conventional chemotherapy used successively or in combination, in order to maximize survival and minimize morbidity. A working knowledge of anti-cancer drug classification will aid the radiologist in assessing response on imaging.
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spelling pubmed-88992282022-03-08 A radiologist’s guide to novel anticancer therapies in the era of precision medicine Khader, Ali Bokhari, Rozan Hakimelahi, Reza Scheirey, Christopher Afnan, Jalil Braschi-Amirfarzan, Marta Thomas, Richard Eur J Radiol Open Article Novel anticancer agents have replaced conventional chemotherapy as first line agents for many cancers, with continued new and expanding indications. Small molecule inhibitors act on cell surface or intracellular targets and prevent the downstream signaling that would otherwise permit tumor growth and spread. Anticancer antibodies can be directed against growth factors or may be immunotherapeutic agents. The latter act by inhibiting mechanisms that cancer cells use to evade the immune system. Hormonal agents act by decreasing levels of hormones that are necessary for the growth of certain cancer cells. Cancer therapy protocols often include novel anticancer agents and conventional chemotherapy used successively or in combination, in order to maximize survival and minimize morbidity. A working knowledge of anti-cancer drug classification will aid the radiologist in assessing response on imaging. Elsevier 2022-03-02 /pmc/articles/PMC8899228/ /pubmed/35265736 http://dx.doi.org/10.1016/j.ejro.2022.100406 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Khader, Ali
Bokhari, Rozan
Hakimelahi, Reza
Scheirey, Christopher
Afnan, Jalil
Braschi-Amirfarzan, Marta
Thomas, Richard
A radiologist’s guide to novel anticancer therapies in the era of precision medicine
title A radiologist’s guide to novel anticancer therapies in the era of precision medicine
title_full A radiologist’s guide to novel anticancer therapies in the era of precision medicine
title_fullStr A radiologist’s guide to novel anticancer therapies in the era of precision medicine
title_full_unstemmed A radiologist’s guide to novel anticancer therapies in the era of precision medicine
title_short A radiologist’s guide to novel anticancer therapies in the era of precision medicine
title_sort radiologist’s guide to novel anticancer therapies in the era of precision medicine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899228/
https://www.ncbi.nlm.nih.gov/pubmed/35265736
http://dx.doi.org/10.1016/j.ejro.2022.100406
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