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A radiologist’s guide to novel anticancer therapies in the era of precision medicine
Novel anticancer agents have replaced conventional chemotherapy as first line agents for many cancers, with continued new and expanding indications. Small molecule inhibitors act on cell surface or intracellular targets and prevent the downstream signaling that would otherwise permit tumor growth an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899228/ https://www.ncbi.nlm.nih.gov/pubmed/35265736 http://dx.doi.org/10.1016/j.ejro.2022.100406 |
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author | Khader, Ali Bokhari, Rozan Hakimelahi, Reza Scheirey, Christopher Afnan, Jalil Braschi-Amirfarzan, Marta Thomas, Richard |
author_facet | Khader, Ali Bokhari, Rozan Hakimelahi, Reza Scheirey, Christopher Afnan, Jalil Braschi-Amirfarzan, Marta Thomas, Richard |
author_sort | Khader, Ali |
collection | PubMed |
description | Novel anticancer agents have replaced conventional chemotherapy as first line agents for many cancers, with continued new and expanding indications. Small molecule inhibitors act on cell surface or intracellular targets and prevent the downstream signaling that would otherwise permit tumor growth and spread. Anticancer antibodies can be directed against growth factors or may be immunotherapeutic agents. The latter act by inhibiting mechanisms that cancer cells use to evade the immune system. Hormonal agents act by decreasing levels of hormones that are necessary for the growth of certain cancer cells. Cancer therapy protocols often include novel anticancer agents and conventional chemotherapy used successively or in combination, in order to maximize survival and minimize morbidity. A working knowledge of anti-cancer drug classification will aid the radiologist in assessing response on imaging. |
format | Online Article Text |
id | pubmed-8899228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88992282022-03-08 A radiologist’s guide to novel anticancer therapies in the era of precision medicine Khader, Ali Bokhari, Rozan Hakimelahi, Reza Scheirey, Christopher Afnan, Jalil Braschi-Amirfarzan, Marta Thomas, Richard Eur J Radiol Open Article Novel anticancer agents have replaced conventional chemotherapy as first line agents for many cancers, with continued new and expanding indications. Small molecule inhibitors act on cell surface or intracellular targets and prevent the downstream signaling that would otherwise permit tumor growth and spread. Anticancer antibodies can be directed against growth factors or may be immunotherapeutic agents. The latter act by inhibiting mechanisms that cancer cells use to evade the immune system. Hormonal agents act by decreasing levels of hormones that are necessary for the growth of certain cancer cells. Cancer therapy protocols often include novel anticancer agents and conventional chemotherapy used successively or in combination, in order to maximize survival and minimize morbidity. A working knowledge of anti-cancer drug classification will aid the radiologist in assessing response on imaging. Elsevier 2022-03-02 /pmc/articles/PMC8899228/ /pubmed/35265736 http://dx.doi.org/10.1016/j.ejro.2022.100406 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Khader, Ali Bokhari, Rozan Hakimelahi, Reza Scheirey, Christopher Afnan, Jalil Braschi-Amirfarzan, Marta Thomas, Richard A radiologist’s guide to novel anticancer therapies in the era of precision medicine |
title | A radiologist’s guide to novel anticancer therapies in the era of precision medicine |
title_full | A radiologist’s guide to novel anticancer therapies in the era of precision medicine |
title_fullStr | A radiologist’s guide to novel anticancer therapies in the era of precision medicine |
title_full_unstemmed | A radiologist’s guide to novel anticancer therapies in the era of precision medicine |
title_short | A radiologist’s guide to novel anticancer therapies in the era of precision medicine |
title_sort | radiologist’s guide to novel anticancer therapies in the era of precision medicine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899228/ https://www.ncbi.nlm.nih.gov/pubmed/35265736 http://dx.doi.org/10.1016/j.ejro.2022.100406 |
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