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Cell-to-Cell Communications in Alcohol-Associated Liver Disease

This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liver disease progression and involves multiple mecha...

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Autores principales: Osna, Natalia A., Eguchi, Akiko, Feldstein, Ariel E., Tsukamoto, Hidekazu, Dagur, Raghubendra S., Ganesan, Murali, New-Aaron, Moses, Arumugam, Madan Kumar, Chava, Srinivas, Ribeiro, Marcelle, Szabo, Gyongyi, Mueller, Sebastian, Wang, Shijin, Chen, Cheng, Weinman, Steven A., Kharbanda, Kusum K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899290/
https://www.ncbi.nlm.nih.gov/pubmed/35264978
http://dx.doi.org/10.3389/fphys.2022.831004
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author Osna, Natalia A.
Eguchi, Akiko
Feldstein, Ariel E.
Tsukamoto, Hidekazu
Dagur, Raghubendra S.
Ganesan, Murali
New-Aaron, Moses
Arumugam, Madan Kumar
Chava, Srinivas
Ribeiro, Marcelle
Szabo, Gyongyi
Mueller, Sebastian
Wang, Shijin
Chen, Cheng
Weinman, Steven A.
Kharbanda, Kusum K.
author_facet Osna, Natalia A.
Eguchi, Akiko
Feldstein, Ariel E.
Tsukamoto, Hidekazu
Dagur, Raghubendra S.
Ganesan, Murali
New-Aaron, Moses
Arumugam, Madan Kumar
Chava, Srinivas
Ribeiro, Marcelle
Szabo, Gyongyi
Mueller, Sebastian
Wang, Shijin
Chen, Cheng
Weinman, Steven A.
Kharbanda, Kusum K.
author_sort Osna, Natalia A.
collection PubMed
description This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liver disease progression and involves multiple mechanisms, such as direct cell-to-cell interactions, extracellular vesicles (EVs) or chemokines, cytokines, and growth factors contained in extracellular fluids/cell culture supernatants. Here, we highlighted the role of EVs derived from alcohol-exposed hepatocytes (HCs) in activation of non-parenchymal cells, liver macrophages (LM), and hepatic stellate cells (HSC). The review also concentrates on EV-mediated crosstalk between liver parenchymal and non-parenchymal cells in the settings of HIV- and alcohol co-exposure. In addition, we overviewed the literature on the crosstalk between cell death pathways and inflammasome activation in alcohol-activated HCs and macrophages. Furthermore, we covered highly clinically relevant studies on the role of non-inflammatory factors, sinusoidal pressure (SP), and hepatic arterialization in alcohol-induced hepatic fibrogenesis. We strongly believe that the review will disclose major mechanisms of cell-to-cell communications pertained to alcohol-induced liver injury progression and will identify therapeutically important targets, which can be used for alcohol-associated liver disease (ALD) prevention.
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spelling pubmed-88992902022-03-08 Cell-to-Cell Communications in Alcohol-Associated Liver Disease Osna, Natalia A. Eguchi, Akiko Feldstein, Ariel E. Tsukamoto, Hidekazu Dagur, Raghubendra S. Ganesan, Murali New-Aaron, Moses Arumugam, Madan Kumar Chava, Srinivas Ribeiro, Marcelle Szabo, Gyongyi Mueller, Sebastian Wang, Shijin Chen, Cheng Weinman, Steven A. Kharbanda, Kusum K. Front Physiol Physiology This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liver disease progression and involves multiple mechanisms, such as direct cell-to-cell interactions, extracellular vesicles (EVs) or chemokines, cytokines, and growth factors contained in extracellular fluids/cell culture supernatants. Here, we highlighted the role of EVs derived from alcohol-exposed hepatocytes (HCs) in activation of non-parenchymal cells, liver macrophages (LM), and hepatic stellate cells (HSC). The review also concentrates on EV-mediated crosstalk between liver parenchymal and non-parenchymal cells in the settings of HIV- and alcohol co-exposure. In addition, we overviewed the literature on the crosstalk between cell death pathways and inflammasome activation in alcohol-activated HCs and macrophages. Furthermore, we covered highly clinically relevant studies on the role of non-inflammatory factors, sinusoidal pressure (SP), and hepatic arterialization in alcohol-induced hepatic fibrogenesis. We strongly believe that the review will disclose major mechanisms of cell-to-cell communications pertained to alcohol-induced liver injury progression and will identify therapeutically important targets, which can be used for alcohol-associated liver disease (ALD) prevention. Frontiers Media S.A. 2022-02-21 /pmc/articles/PMC8899290/ /pubmed/35264978 http://dx.doi.org/10.3389/fphys.2022.831004 Text en Copyright © 2022 Osna, Eguchi, Feldstein, Tsukamoto, Dagur, Ganesan, New-Aaron, Arumugam, Chava, Ribeiro, Szabo, Mueller, Wang, Chen, Weinman and Kharbanda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Osna, Natalia A.
Eguchi, Akiko
Feldstein, Ariel E.
Tsukamoto, Hidekazu
Dagur, Raghubendra S.
Ganesan, Murali
New-Aaron, Moses
Arumugam, Madan Kumar
Chava, Srinivas
Ribeiro, Marcelle
Szabo, Gyongyi
Mueller, Sebastian
Wang, Shijin
Chen, Cheng
Weinman, Steven A.
Kharbanda, Kusum K.
Cell-to-Cell Communications in Alcohol-Associated Liver Disease
title Cell-to-Cell Communications in Alcohol-Associated Liver Disease
title_full Cell-to-Cell Communications in Alcohol-Associated Liver Disease
title_fullStr Cell-to-Cell Communications in Alcohol-Associated Liver Disease
title_full_unstemmed Cell-to-Cell Communications in Alcohol-Associated Liver Disease
title_short Cell-to-Cell Communications in Alcohol-Associated Liver Disease
title_sort cell-to-cell communications in alcohol-associated liver disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899290/
https://www.ncbi.nlm.nih.gov/pubmed/35264978
http://dx.doi.org/10.3389/fphys.2022.831004
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