Cargando…
Cell-to-Cell Communications in Alcohol-Associated Liver Disease
This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liver disease progression and involves multiple mecha...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899290/ https://www.ncbi.nlm.nih.gov/pubmed/35264978 http://dx.doi.org/10.3389/fphys.2022.831004 |
_version_ | 1784663890274025472 |
---|---|
author | Osna, Natalia A. Eguchi, Akiko Feldstein, Ariel E. Tsukamoto, Hidekazu Dagur, Raghubendra S. Ganesan, Murali New-Aaron, Moses Arumugam, Madan Kumar Chava, Srinivas Ribeiro, Marcelle Szabo, Gyongyi Mueller, Sebastian Wang, Shijin Chen, Cheng Weinman, Steven A. Kharbanda, Kusum K. |
author_facet | Osna, Natalia A. Eguchi, Akiko Feldstein, Ariel E. Tsukamoto, Hidekazu Dagur, Raghubendra S. Ganesan, Murali New-Aaron, Moses Arumugam, Madan Kumar Chava, Srinivas Ribeiro, Marcelle Szabo, Gyongyi Mueller, Sebastian Wang, Shijin Chen, Cheng Weinman, Steven A. Kharbanda, Kusum K. |
author_sort | Osna, Natalia A. |
collection | PubMed |
description | This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liver disease progression and involves multiple mechanisms, such as direct cell-to-cell interactions, extracellular vesicles (EVs) or chemokines, cytokines, and growth factors contained in extracellular fluids/cell culture supernatants. Here, we highlighted the role of EVs derived from alcohol-exposed hepatocytes (HCs) in activation of non-parenchymal cells, liver macrophages (LM), and hepatic stellate cells (HSC). The review also concentrates on EV-mediated crosstalk between liver parenchymal and non-parenchymal cells in the settings of HIV- and alcohol co-exposure. In addition, we overviewed the literature on the crosstalk between cell death pathways and inflammasome activation in alcohol-activated HCs and macrophages. Furthermore, we covered highly clinically relevant studies on the role of non-inflammatory factors, sinusoidal pressure (SP), and hepatic arterialization in alcohol-induced hepatic fibrogenesis. We strongly believe that the review will disclose major mechanisms of cell-to-cell communications pertained to alcohol-induced liver injury progression and will identify therapeutically important targets, which can be used for alcohol-associated liver disease (ALD) prevention. |
format | Online Article Text |
id | pubmed-8899290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88992902022-03-08 Cell-to-Cell Communications in Alcohol-Associated Liver Disease Osna, Natalia A. Eguchi, Akiko Feldstein, Ariel E. Tsukamoto, Hidekazu Dagur, Raghubendra S. Ganesan, Murali New-Aaron, Moses Arumugam, Madan Kumar Chava, Srinivas Ribeiro, Marcelle Szabo, Gyongyi Mueller, Sebastian Wang, Shijin Chen, Cheng Weinman, Steven A. Kharbanda, Kusum K. Front Physiol Physiology This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liver disease progression and involves multiple mechanisms, such as direct cell-to-cell interactions, extracellular vesicles (EVs) or chemokines, cytokines, and growth factors contained in extracellular fluids/cell culture supernatants. Here, we highlighted the role of EVs derived from alcohol-exposed hepatocytes (HCs) in activation of non-parenchymal cells, liver macrophages (LM), and hepatic stellate cells (HSC). The review also concentrates on EV-mediated crosstalk between liver parenchymal and non-parenchymal cells in the settings of HIV- and alcohol co-exposure. In addition, we overviewed the literature on the crosstalk between cell death pathways and inflammasome activation in alcohol-activated HCs and macrophages. Furthermore, we covered highly clinically relevant studies on the role of non-inflammatory factors, sinusoidal pressure (SP), and hepatic arterialization in alcohol-induced hepatic fibrogenesis. We strongly believe that the review will disclose major mechanisms of cell-to-cell communications pertained to alcohol-induced liver injury progression and will identify therapeutically important targets, which can be used for alcohol-associated liver disease (ALD) prevention. Frontiers Media S.A. 2022-02-21 /pmc/articles/PMC8899290/ /pubmed/35264978 http://dx.doi.org/10.3389/fphys.2022.831004 Text en Copyright © 2022 Osna, Eguchi, Feldstein, Tsukamoto, Dagur, Ganesan, New-Aaron, Arumugam, Chava, Ribeiro, Szabo, Mueller, Wang, Chen, Weinman and Kharbanda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Osna, Natalia A. Eguchi, Akiko Feldstein, Ariel E. Tsukamoto, Hidekazu Dagur, Raghubendra S. Ganesan, Murali New-Aaron, Moses Arumugam, Madan Kumar Chava, Srinivas Ribeiro, Marcelle Szabo, Gyongyi Mueller, Sebastian Wang, Shijin Chen, Cheng Weinman, Steven A. Kharbanda, Kusum K. Cell-to-Cell Communications in Alcohol-Associated Liver Disease |
title | Cell-to-Cell Communications in Alcohol-Associated Liver Disease |
title_full | Cell-to-Cell Communications in Alcohol-Associated Liver Disease |
title_fullStr | Cell-to-Cell Communications in Alcohol-Associated Liver Disease |
title_full_unstemmed | Cell-to-Cell Communications in Alcohol-Associated Liver Disease |
title_short | Cell-to-Cell Communications in Alcohol-Associated Liver Disease |
title_sort | cell-to-cell communications in alcohol-associated liver disease |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899290/ https://www.ncbi.nlm.nih.gov/pubmed/35264978 http://dx.doi.org/10.3389/fphys.2022.831004 |
work_keys_str_mv | AT osnanataliaa celltocellcommunicationsinalcoholassociatedliverdisease AT eguchiakiko celltocellcommunicationsinalcoholassociatedliverdisease AT feldsteinariele celltocellcommunicationsinalcoholassociatedliverdisease AT tsukamotohidekazu celltocellcommunicationsinalcoholassociatedliverdisease AT dagurraghubendras celltocellcommunicationsinalcoholassociatedliverdisease AT ganesanmurali celltocellcommunicationsinalcoholassociatedliverdisease AT newaaronmoses celltocellcommunicationsinalcoholassociatedliverdisease AT arumugammadankumar celltocellcommunicationsinalcoholassociatedliverdisease AT chavasrinivas celltocellcommunicationsinalcoholassociatedliverdisease AT ribeiromarcelle celltocellcommunicationsinalcoholassociatedliverdisease AT szabogyongyi celltocellcommunicationsinalcoholassociatedliverdisease AT muellersebastian celltocellcommunicationsinalcoholassociatedliverdisease AT wangshijin celltocellcommunicationsinalcoholassociatedliverdisease AT chencheng celltocellcommunicationsinalcoholassociatedliverdisease AT weinmanstevena celltocellcommunicationsinalcoholassociatedliverdisease AT kharbandakusumk celltocellcommunicationsinalcoholassociatedliverdisease |