Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?

The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and whether this new in...

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Detalles Bibliográficos
Autores principales: Dockrell, Hazel M., Butkeviciute, Egle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899334/
https://www.ncbi.nlm.nih.gov/pubmed/33583672
http://dx.doi.org/10.1016/j.vaccine.2021.01.068
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author Dockrell, Hazel M.
Butkeviciute, Egle
author_facet Dockrell, Hazel M.
Butkeviciute, Egle
author_sort Dockrell, Hazel M.
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description The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and whether this new information can be exploited to improve its efficacy, by enhancing its ability to induce either antigen-specific and/or non-specific effects. Many factors affect both the immunogenicity of BCG and its protective efficacy, highlighting the challenges of working with a live vaccine in man, but new insights may enable us to exploit better what BCG can do.
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spelling pubmed-88993342022-03-11 Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine? Dockrell, Hazel M. Butkeviciute, Egle Vaccine Article The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and whether this new information can be exploited to improve its efficacy, by enhancing its ability to induce either antigen-specific and/or non-specific effects. Many factors affect both the immunogenicity of BCG and its protective efficacy, highlighting the challenges of working with a live vaccine in man, but new insights may enable us to exploit better what BCG can do. Elsevier Science 2022-03-08 /pmc/articles/PMC8899334/ /pubmed/33583672 http://dx.doi.org/10.1016/j.vaccine.2021.01.068 Text en © 2021 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dockrell, Hazel M.
Butkeviciute, Egle
Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?
title Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?
title_full Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?
title_fullStr Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?
title_full_unstemmed Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?
title_short Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?
title_sort can what have we learnt about bcg vaccination in the last 20 years help us to design a better tuberculosis vaccine?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899334/
https://www.ncbi.nlm.nih.gov/pubmed/33583672
http://dx.doi.org/10.1016/j.vaccine.2021.01.068
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