Cargando…
miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma
Numerous studies have found a relationship between cancer formation and aberrant microRNA expression, however the biological significance of miR-497-5p in glioblastoma (GBM) is still unknown. Compared to normal brain glial cells, miR-497-5p expression in GBM tissues was substantially lower in our st...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899375/ https://www.ncbi.nlm.nih.gov/pubmed/35281864 http://dx.doi.org/10.7150/jca.62652 |
_version_ | 1784663899741618176 |
---|---|
author | Chen, Kun Wang, Zheng Zong, Qi-Bei Zhou, Meng-Ying Chen, Qing-Fa |
author_facet | Chen, Kun Wang, Zheng Zong, Qi-Bei Zhou, Meng-Ying Chen, Qing-Fa |
author_sort | Chen, Kun |
collection | PubMed |
description | Numerous studies have found a relationship between cancer formation and aberrant microRNA expression, however the biological significance of miR-497-5p in glioblastoma (GBM) is still unknown. Compared to normal brain glial cells, miR-497-5p expression in GBM tissues was substantially lower in our study. The microRNA miR-497-5p targets R-spondin 2 (RSPO2) only when it is present. RSPO2 silencing has the same effect on GBM cells as miR-497-5p silencing, as demonstrated before. Additional mechanistic investigations have shown that miR-497-5p suppresses the Wnt/β-catenin signaling pathway by targeting RSPO2 to reduce cell proliferation, migration, and invasion. A negative correlation was discovered between MiR-497-5p and RSPO2 in 37 of the GBM tumors studied. MiR-497-5p-RSPO2 axis controls Wnt/β-catenin signaling and plays a function in GBM carcinogenesis, suggesting that it may be a therapeutic target to reduce GBM growth, as shown by our research findings. |
format | Online Article Text |
id | pubmed-8899375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-88993752022-03-11 miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma Chen, Kun Wang, Zheng Zong, Qi-Bei Zhou, Meng-Ying Chen, Qing-Fa J Cancer Research Paper Numerous studies have found a relationship between cancer formation and aberrant microRNA expression, however the biological significance of miR-497-5p in glioblastoma (GBM) is still unknown. Compared to normal brain glial cells, miR-497-5p expression in GBM tissues was substantially lower in our study. The microRNA miR-497-5p targets R-spondin 2 (RSPO2) only when it is present. RSPO2 silencing has the same effect on GBM cells as miR-497-5p silencing, as demonstrated before. Additional mechanistic investigations have shown that miR-497-5p suppresses the Wnt/β-catenin signaling pathway by targeting RSPO2 to reduce cell proliferation, migration, and invasion. A negative correlation was discovered between MiR-497-5p and RSPO2 in 37 of the GBM tumors studied. MiR-497-5p-RSPO2 axis controls Wnt/β-catenin signaling and plays a function in GBM carcinogenesis, suggesting that it may be a therapeutic target to reduce GBM growth, as shown by our research findings. Ivyspring International Publisher 2022-01-24 /pmc/articles/PMC8899375/ /pubmed/35281864 http://dx.doi.org/10.7150/jca.62652 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Chen, Kun Wang, Zheng Zong, Qi-Bei Zhou, Meng-Ying Chen, Qing-Fa miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma |
title | miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma |
title_full | miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma |
title_fullStr | miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma |
title_full_unstemmed | miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma |
title_short | miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma |
title_sort | mir-497-5p-rspo2 axis inhibits cell growth and metastasis in glioblastoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899375/ https://www.ncbi.nlm.nih.gov/pubmed/35281864 http://dx.doi.org/10.7150/jca.62652 |
work_keys_str_mv | AT chenkun mir4975prspo2axisinhibitscellgrowthandmetastasisinglioblastoma AT wangzheng mir4975prspo2axisinhibitscellgrowthandmetastasisinglioblastoma AT zongqibei mir4975prspo2axisinhibitscellgrowthandmetastasisinglioblastoma AT zhoumengying mir4975prspo2axisinhibitscellgrowthandmetastasisinglioblastoma AT chenqingfa mir4975prspo2axisinhibitscellgrowthandmetastasisinglioblastoma |