mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells

mTOR activation is a hallmark of T-cell acute lymphoblastic leukemia (T-ALL) and is associated with resistance to glucocorticoid (GC)-based chemotherapy. We previously showed that altering redox homeostasis primes T-ALL cells to GC-induced apoptosis. Here we investigated the connection between the m...

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Detalles Bibliográficos
Autores principales: Silic-Benussi, Micol, Sharova, Evgenyia, Ciccarese, Francesco, Cavallari, Ilaria, Raimondi, Vittoria, Urso, Loredana, Corradin, Alberto, Kotler, Harel, Scattolin, Gloria, Buldini, Barbara, Francescato, Samuela, Basso, Giuseppe, Minuzzo, Sonia A., Indraccolo, Stefano, D'Agostino, Donna M., Ciminale, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899410/
https://www.ncbi.nlm.nih.gov/pubmed/35248829
http://dx.doi.org/10.1016/j.redox.2022.102268

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