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Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia

In the arousal process, the brain restores its integrative activity from the synchronized state of slow wave activity (SWA). The mechanisms underpinning this state transition remain, however, to be elucidated. Here we simultaneously probed neuronal assemblies throughout the whole cortex with micro-e...

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Autores principales: Pazienti, Antonio, Galluzzi, Andrea, Dasilva, Miguel, Sanchez-Vives, Maria V., Mattia, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899414/
https://www.ncbi.nlm.nih.gov/pubmed/35265807
http://dx.doi.org/10.1016/j.isci.2022.103918
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author Pazienti, Antonio
Galluzzi, Andrea
Dasilva, Miguel
Sanchez-Vives, Maria V.
Mattia, Maurizio
author_facet Pazienti, Antonio
Galluzzi, Andrea
Dasilva, Miguel
Sanchez-Vives, Maria V.
Mattia, Maurizio
author_sort Pazienti, Antonio
collection PubMed
description In the arousal process, the brain restores its integrative activity from the synchronized state of slow wave activity (SWA). The mechanisms underpinning this state transition remain, however, to be elucidated. Here we simultaneously probed neuronal assemblies throughout the whole cortex with micro-electrocorticographic recordings in mice. We investigated the progressive shaping of propagating SWA at different levels of isoflurane. We found a form of memory of the wavefront shapes at deep anesthesia, tightly alternating posterior-anterior-posterior patterns. At low isoflurane, metastable patterns propagated in more directions, reflecting an increased complexity. The wandering across these mesostates progressively increased its randomness, as predicted by simulations of a network of spiking neurons, and confirmed in our experimental data. The complexity increase is explained by the elevated excitability of local assemblies with no modifications of the network connectivity. These results shed new light on the functional reorganization of the cortical network as anesthesia fades out.
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spelling pubmed-88994142022-03-08 Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia Pazienti, Antonio Galluzzi, Andrea Dasilva, Miguel Sanchez-Vives, Maria V. Mattia, Maurizio iScience Article In the arousal process, the brain restores its integrative activity from the synchronized state of slow wave activity (SWA). The mechanisms underpinning this state transition remain, however, to be elucidated. Here we simultaneously probed neuronal assemblies throughout the whole cortex with micro-electrocorticographic recordings in mice. We investigated the progressive shaping of propagating SWA at different levels of isoflurane. We found a form of memory of the wavefront shapes at deep anesthesia, tightly alternating posterior-anterior-posterior patterns. At low isoflurane, metastable patterns propagated in more directions, reflecting an increased complexity. The wandering across these mesostates progressively increased its randomness, as predicted by simulations of a network of spiking neurons, and confirmed in our experimental data. The complexity increase is explained by the elevated excitability of local assemblies with no modifications of the network connectivity. These results shed new light on the functional reorganization of the cortical network as anesthesia fades out. Elsevier 2022-02-12 /pmc/articles/PMC8899414/ /pubmed/35265807 http://dx.doi.org/10.1016/j.isci.2022.103918 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Pazienti, Antonio
Galluzzi, Andrea
Dasilva, Miguel
Sanchez-Vives, Maria V.
Mattia, Maurizio
Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
title Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
title_full Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
title_fullStr Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
title_full_unstemmed Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
title_short Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
title_sort slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899414/
https://www.ncbi.nlm.nih.gov/pubmed/35265807
http://dx.doi.org/10.1016/j.isci.2022.103918
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