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Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
In the arousal process, the brain restores its integrative activity from the synchronized state of slow wave activity (SWA). The mechanisms underpinning this state transition remain, however, to be elucidated. Here we simultaneously probed neuronal assemblies throughout the whole cortex with micro-e...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899414/ https://www.ncbi.nlm.nih.gov/pubmed/35265807 http://dx.doi.org/10.1016/j.isci.2022.103918 |
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author | Pazienti, Antonio Galluzzi, Andrea Dasilva, Miguel Sanchez-Vives, Maria V. Mattia, Maurizio |
author_facet | Pazienti, Antonio Galluzzi, Andrea Dasilva, Miguel Sanchez-Vives, Maria V. Mattia, Maurizio |
author_sort | Pazienti, Antonio |
collection | PubMed |
description | In the arousal process, the brain restores its integrative activity from the synchronized state of slow wave activity (SWA). The mechanisms underpinning this state transition remain, however, to be elucidated. Here we simultaneously probed neuronal assemblies throughout the whole cortex with micro-electrocorticographic recordings in mice. We investigated the progressive shaping of propagating SWA at different levels of isoflurane. We found a form of memory of the wavefront shapes at deep anesthesia, tightly alternating posterior-anterior-posterior patterns. At low isoflurane, metastable patterns propagated in more directions, reflecting an increased complexity. The wandering across these mesostates progressively increased its randomness, as predicted by simulations of a network of spiking neurons, and confirmed in our experimental data. The complexity increase is explained by the elevated excitability of local assemblies with no modifications of the network connectivity. These results shed new light on the functional reorganization of the cortical network as anesthesia fades out. |
format | Online Article Text |
id | pubmed-8899414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88994142022-03-08 Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia Pazienti, Antonio Galluzzi, Andrea Dasilva, Miguel Sanchez-Vives, Maria V. Mattia, Maurizio iScience Article In the arousal process, the brain restores its integrative activity from the synchronized state of slow wave activity (SWA). The mechanisms underpinning this state transition remain, however, to be elucidated. Here we simultaneously probed neuronal assemblies throughout the whole cortex with micro-electrocorticographic recordings in mice. We investigated the progressive shaping of propagating SWA at different levels of isoflurane. We found a form of memory of the wavefront shapes at deep anesthesia, tightly alternating posterior-anterior-posterior patterns. At low isoflurane, metastable patterns propagated in more directions, reflecting an increased complexity. The wandering across these mesostates progressively increased its randomness, as predicted by simulations of a network of spiking neurons, and confirmed in our experimental data. The complexity increase is explained by the elevated excitability of local assemblies with no modifications of the network connectivity. These results shed new light on the functional reorganization of the cortical network as anesthesia fades out. Elsevier 2022-02-12 /pmc/articles/PMC8899414/ /pubmed/35265807 http://dx.doi.org/10.1016/j.isci.2022.103918 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Pazienti, Antonio Galluzzi, Andrea Dasilva, Miguel Sanchez-Vives, Maria V. Mattia, Maurizio Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia |
title | Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia |
title_full | Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia |
title_fullStr | Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia |
title_full_unstemmed | Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia |
title_short | Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia |
title_sort | slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899414/ https://www.ncbi.nlm.nih.gov/pubmed/35265807 http://dx.doi.org/10.1016/j.isci.2022.103918 |
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