Interplay between mitochondrial reactive oxygen species, oxidative stress and hypoxic adaptation in facioscapulohumeral muscular dystrophy: Metabolic stress as potential therapeutic target

Facioscapulohumeral muscular dystrophy (FSHD) is characterised by descending skeletal muscle weakness and wasting. FSHD is caused by mis-expression of the transcription factor DUX4, which is linked to oxidative stress, a condition especially detrimental to skeletal muscle with its high metabolic act...

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Detalles Bibliográficos
Autores principales: Heher, Philipp, Ganassi, Massimo, Weidinger, Adelheid, Engquist, Elise N., Pruller, Johanna, Nguyen, Thuy Hang, Tassin, Alexandra, Declèves, Anne-Emilie, Mamchaoui, Kamel, Banerji, Christopher R.S., Grillari, Johannes, Kozlov, Andrey V., Zammit, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899416/
https://www.ncbi.nlm.nih.gov/pubmed/35248827
http://dx.doi.org/10.1016/j.redox.2022.102251

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