Enhancing CAR T function with the engineered secretion of C. perfringens neuraminidase

Prior to adoptive transfer, CAR T cells are activated, lentivirally infected with CAR transgenes, and expanded over 9 to 11 days. An unintended consequence of this process is the progressive differentiation of CAR T cells over time in culture. Differentiated T cells engraft poorly, which limits thei...

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Detalles Bibliográficos
Autores principales: Durgin, Joseph S., Thokala, Radhika, Johnson, Lexus, Song, Edward, Leferovich, John, Bhoj, Vijay, Ghassemi, Saba, Milone, Michael, Binder, Zev, O'Rourke, Donald M., O'Connor, Roddy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899523/
https://www.ncbi.nlm.nih.gov/pubmed/34813961
http://dx.doi.org/10.1016/j.ymthe.2021.11.014

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