Cargando…

Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration

The nucleus pulposus (NP), a heterogeneous tissue, is an essential functional component of the intervertebral disc. However, NP cell development route and regulation mechanism in intervertebral disc degeneration (IVDD) remain unknown. Here, we performed single-cell RNA sequencing of six NP samples w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Shuo, Zhang, Yiran, Zhang, Xianjuan, Zhang, Hao, Meng, Shengwei, Kong, Meng, Liu, Xiaojie, Ma, Xuexiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899542/ https://www.ncbi.nlm.nih.gov/pubmed/35265617 http://dx.doi.org/10.3389/fcell.2022.824771

Ejemplares similares

PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells
por: Zhang, Zhenlei, et al.
Publicado: (2022)

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells
por: Xie, Chenglong, et al.
Publicado: (2022)

Myocardin-related transcription factor A nuclear translocation contributes to mechanical overload-induced nucleus pulposus fibrosis in rats with intervertebral disc degeneration
por: Kong, Meng, et al.
Publicado: (2021)

The role of ferroptosis in intervertebral disc degeneration
por: Fan, Chunyang, et al.
Publicado: (2023)

Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
por: Kim, Ki-Won, et al.
Publicado: (2008)

Ex Vivo Observation of Human Nucleus Pulposus Chondrocytes Isolated From Degenerated Intervertebral Discs
por: Wang, Feng, et al.
Publicado: (2011)

Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration
por: Qiu, Chensheng, et al.
Publicado: (2020)

Fexofenadine Protects Against Intervertebral Disc Degeneration Through TNF Signaling
por: Liu, Kaiwen, et al.
Publicado: (2021)

Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells
por: Bao, Junping, et al.
Publicado: (2021)

Exosomes Immunity Strategy: A Novel Approach for Ameliorating Intervertebral Disc Degeneration
por: Li, Weihang, et al.
Publicado: (2022)

Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration
por: Huang, Huagui, et al.
Publicado: (2023)

Effects of puerarin on the intervertebral disc degeneration and biological characteristics of nucleus pulposus cells
por: Tang, Hengtao, et al.
Publicado: (2022)

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration
por: Chen, Hai-Wei, et al.
Publicado: (2021)

Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration
por: Wang, Dong, et al.
Publicado: (2022)

Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration
por: Wu, Xinjie, et al.
Publicado: (2022)

Editorial: Immunological imbalance: What is its role in intervertebral disc degeneration?
por: Gantenbein, Benjamin, et al.
Publicado: (2023)

Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone
por: Hagizawa, Hiroki, et al.
Publicado: (2023)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration
por: Li, Zheng, et al.
Publicado: (2019)

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
por: Che, Hui, et al.
Publicado: (2020)

Role of ferroptosis and immune infiltration in intervertebral disc degeneration: novel insights from bioinformatics analyses
por: Liu, Xiao-Wei, et al.
Publicado: (2023)

Circ_0005918 Sponges miR-622 to Aggravate Intervertebral Disc Degeneration
por: Cui, Yan, et al.
Publicado: (2022)

Mesenchymal Stem Cell-Derived Exosomes as a Novel Strategy for the Treatment of Intervertebral Disc Degeneration
por: Lu, Lin, et al.
Publicado: (2022)

IGF Signaling in Intervertebral Disc Health and Disease
por: Lin, Hui, et al.
Publicado: (2022)

The Role of miR-31-5p in the Development of Intervertebral Disc Degeneration and Its Therapeutic Potential
por: Zhou, Yong, et al.
Publicado: (2021)

Expression of ANGPTL4 in Nucleus Pulposus Tissues Is Associated with Intervertebral Disc Degeneration
por: Liu, Fan-jie, et al.
Publicado: (2021)

Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc Degeneration
por: Ling, Zemin, et al.
Publicado: (2022)

Effects of the NF-κB/p53 signaling pathway on intervertebral disc nucleus pulposus degeneration
por: Zhang, Litao, et al.
Publicado: (2020)

TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc Degeneration
por: Zhang, Guangzhi, et al.
Publicado: (2023)

Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy
por: Luo, Liwen, et al.
Publicado: (2021)

The Upregulation of COX2 in Human Degenerated Nucleus Pulposus: The Association of Inflammation with Intervertebral Disc Degeneration
por: Liu, Chang, et al.
Publicado: (2021)

Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway
por: Wang, Dong, et al.
Publicado: (2020)

The new ceRNA crosstalk between mRNAs and miRNAs in intervertebral disc degeneration
por: Li, Xingye, et al.
Publicado: (2022)

Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells
por: Mohanty, Sarthak, et al.
Publicado: (2019)

Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration
por: Li, Shuai, et al.
Publicado: (2021)

HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages
por: Zhang, Shuo, et al.
Publicado: (2022)

Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes
por: Luo, Liwen, et al.
Publicado: (2021)

Injectable hydrogel with nucleus pulposus-matched viscoelastic property prevents intervertebral disc degeneration
por: Jia, Haoruo, et al.
Publicado: (2022)

Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration
por: Gao, Bo, et al.
Publicado: (2022)

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
por: Zhang, Guang‐Zhi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cq6p6fmc4a3hhpkif3qtf3o3hu