Targeting the anti-apoptotic Bcl-2 family proteins: machine learning virtual screening and biological evaluation of new small molecules

Bcl-2 family anti-apoptotic proteins are overexpressed in several hematological and solid tumors, and contribute to tumor formation, progression, and resistance to therapy. They represent a promising therapeutic avenue to explore for cancer treatment. Venetoclax, a Bcl-2 inhibitor is currently used...

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Detalles Bibliográficos
Autores principales: Valentini, Elisabetta, D'Aguanno, Simona, Di Martile, Marta, Montesano, Camilla, Ferraresi, Virginia, Patsilinakos, Alexandros, Sabatino, Manuela, Antonini, Lorenzo, Chiacchiarini, Martina, Valente, Sergio, Mai, Antonello, Colotti, Gianni, Ragno, Rino, Trisciuoglio, Daniela, Del Bufalo, Donatella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899577/
https://www.ncbi.nlm.nih.gov/pubmed/35265218
http://dx.doi.org/10.7150/thno.64233

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