SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation

Rationale: While some non-steroidal anti-inflammatory drugs (NSAIDs) are reported to induce hepatic steatosis, the molecular mechanisms are poorly understood. This study presented the mechanism by which NSAIDs induce hepatic lipid accumulation. Methods: Mouse primary hepatocytes and HepG2 cells were...

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Detalles Bibliográficos
Autores principales: Lee, Wonseok, Kim, Hyun Young, Choi, You-Jin, Jung, Seung-Hwan, Nam, Yoon Ah, Zhang, Yunfan, Yun, Sung Ho, Chang, Tong-Shin, Lee, Byung-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899581/
https://www.ncbi.nlm.nih.gov/pubmed/35265214
http://dx.doi.org/10.7150/thno.70692

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