Cargando…

Macitentan improves antitumor immune responses by inhibiting the secretion of tumor-derived extracellular vesicle PD-L1

Extracellular vesicles (EVs) carrying tumor cell-derived programmed death-ligand 1 (PD-L1) interact with programmed death 1 (PD-1)-producing T cells, thus significantly lowering a patient's response to immune checkpoint blockade drugs. No drug that reinvigorates CD8+ T cells by suppressing EV P...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Chan-Hyeong, Bae, Ju-Hyun, Choe, Eun-Ji, Park, Ju-Mi, Park, Seong-Sik, Cho, Hee Jin, Song, Byoung-Joon, Baek, Moon-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899590/ https://www.ncbi.nlm.nih.gov/pubmed/35265193 http://dx.doi.org/10.7150/thno.68864

Ejemplares similares

Temsirolimus Enhances Anti-Cancer Immunity by Inducing Autophagy-Mediated Degradation of the Secretion of Small Extracellular Vesicle PD-L1
por: Park, Seong-Sik, et al.
Publicado: (2022)

Atorvastatin Enhances the Efficacy of Immune Checkpoint Therapy and Suppresses the Cellular and Extracellular Vesicle PD-L1
por: Choe, Eun-Ji, et al.
Publicado: (2022)

Reply to ‘Sulfisoxazole does not inhibit the secretion of small extracellular vesicles’
por: Lee, Chan-Hyeong, et al.
Publicado: (2021)

Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
por: Im, Eun-Ju, et al.
Publicado: (2019)

Increased liver-specific proteins in circulating extracellular vesicles as potential biomarkers for drug- and alcohol-induced liver injury
por: Cho, Young-Eun, et al.
Publicado: (2017)

Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles
por: Lee, Chan-Hyeong, et al.
Publicado: (2018)

Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD‐L1
por: Shin, Jung Min, et al.
Publicado: (2021)

Macitentan for the treatment of pulmonary arterial hypertension
por: Kholdani, Cyrus A, et al.
Publicado: (2014)

Boosting extracellular vesicle secretion
por: Debbi, Lior, et al.
Publicado: (2022)

Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses
por: Gargiulo, Ernesto, et al.
Publicado: (2023)

Dendritic Cell-Targeted pH-Responsive Extracellular Vesicles for Anticancer Vaccination
por: Lee, Hyuk, et al.
Publicado: (2019)

Macitentan in pulmonary arterial hypertension: The SERAPHIN trial
por: Said, Karim
Publicado: (2014)

Macitentan in the treatment of pulmonary hypertension in Gaucher’s disease
por: Taylan, Gökay, et al.
Publicado: (2020)

Circulating Extracellular-Vesicle-Incorporated MicroRNAs as Potential Biomarkers for Ischemic Stroke in Patients With Cancer
por: Bang, Oh Young, et al.
Publicado: (2023)

The Role of Extracellular Vesicles in Senescence
por: Oh, Chaehwan, et al.
Publicado: (2022)

Macitentan: An important addition to the treatment of pulmonary arterial hypertension
por: Khadka, Anjan, et al.
Publicado: (2015)

Clinical Pharmacokinetics and Pharmacodynamics of the Endothelin Receptor Antagonist Macitentan
por: Sidharta, P. N., et al.
Publicado: (2015)

The use of Macitentan in Fontan circulation: a case report
por: Demetriades, Polyvios, et al.
Publicado: (2017)

Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer
por: Moon, Pyong-Gon, et al.
Publicado: (2016)

Plant hairy roots for the production of extracellular vesicles with antitumor bioactivity
por: Boccia, Eleonora, et al.
Publicado: (2022)

Adipose stem cell-derived extracellular vesicles ameliorates corticosterone-induced apoptosis in the cortical neurons via inhibition of ER stress
por: Hyun, Sung-Ae, et al.
Publicado: (2022)

Decoding the Secret of Cancer by Means of Extracellular Vesicles
por: Kosaka, Nobuyoshi
Publicado: (2016)

Extracellular Vesicles: An Overlooked Secretion System in Cyanobacteria
por: Lima, Steeve, et al.
Publicado: (2020)

The forces driving cancer extracellular vesicle secretion
por: Bebelman, Maarten P., et al.
Publicado: (2020)

Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles
por: Kim, Min-Hye, et al.
Publicado: (2018)

Swift and Complete Healing of Digital Ulcers after Macitentan Treatment
por: Giner Serret, Emilio
Publicado: (2016)

Benefits from the Early Initiation of Macitentan for Pulmonary Arterial Hypertension
por: Jung, Hae Ok
Publicado: (2018)

Safety and tolerability of macitentan in the management of pulmonary arterial hypertension: an update
por: Wong, Alexandra K, et al.
Publicado: (2019)

Initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension
por: Sitbon, Olivier, et al.
Publicado: (2020)

The Endothelin Receptor Antagonist Macitentan Inhibits Human Cytomegalovirus Infection
por: Landázuri, Natalia, et al.
Publicado: (2021)

Effects of bergapten on the pharmacokinetics of macitentan in rats both in vitro and in vivo
por: Xu, Jia, et al.
Publicado: (2023)

Efficacy and safety of macitentan for pulmonary hypertension: A meta‐analysis
por: Du, Dan, et al.
Publicado: (2023)

Depletion of Mitochondrial Components from Extracellular Vesicles Secreted from Astrocytes in a Mouse Model of Fragile X Syndrome
por: Ha, Byung Geun, et al.
Publicado: (2021)

Microbiota and Extracellular Vesicles in Anti-PD-1/PD-L1 Therapy
por: Mishra, Surbhi, et al.
Publicado: (2022)

Extracellular vesicles for neural regeneration after spinal cord injury
por: Lim, Young-Ju, et al.
Publicado: (2023)

RIG-I activation induces the release of extracellular vesicles with antitumor activity
por: Daßler-Plenker, Juliane, et al.
Publicado: (2016)

Murine Leukemia-Derived Extracellular Vesicles Elicit Antitumor Immune Response
por: Pando, Alejandro, et al.
Publicado: (2021)

The Role of Cancer Stem Cells and Their Extracellular Vesicles in the Modulation of the Antitumor Immunity
por: Chulpanova, Daria S., et al.
Publicado: (2022)

Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles
por: Tse, Shun Wilford, et al.
Publicado: (2020)

Extracellular vesicles: what secrets do they hold inside?
por: Luz, Ishai, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5c564c80nrof41p796o43qnro4