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D2HGDH-mediated D2HG catabolism enhances the anti-tumor activities of CAR-T cells in an immunosuppressive microenvironment

The effect of immunotherapy is limited by oncometabolite D-2-hydroxyglutarate (D2HG). D2HGDH is an inducible enzyme that converts D2HG into the endogenous metabolite 2-oxoglutarate. We aimed to evaluate the impairment of CD8 T lymphocyte function in the high-D2HG environment and to explore the pheno...

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Detalles Bibliográficos
Autores principales:	Yang, Quanjun, Hao, Juan, Chi, Mengyi, Wang, Yaxian, Li, Jie, Huang, Jinlu, Zhang, Jianping, Zhang, Mengqi, Lu, Jin, Zhou, Shumin, Yuan, Ting, Shen, Zan, Zheng, Shuier, Guo, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899596/ https://www.ncbi.nlm.nih.gov/pubmed/35007759 http://dx.doi.org/10.1016/j.ymthe.2022.01.007

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