Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms

Five new oleanane-type triterpenoid saponins (1–5), together with 24 known saponins (6–29) were isolated from the fruit of Acanthopanax senticosus. Their structures were determined by extensive spectroscopic analysis, including 1D, 2D nuclear magnetic resonance (NMR), and high-resolution electrospra...

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Autores principales: Liu, Yan, Jiang, Peng, Zhang, Mei-Ling, Pan, Juan, Guan, Wei, Li, Xiao-Mao, Yang, Bing-You, Kuang, Hai-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899614/
https://www.ncbi.nlm.nih.gov/pubmed/35265584
http://dx.doi.org/10.3389/fchem.2022.825763
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author Liu, Yan
Jiang, Peng
Zhang, Mei-Ling
Pan, Juan
Guan, Wei
Li, Xiao-Mao
Yang, Bing-You
Kuang, Hai-Xue
author_facet Liu, Yan
Jiang, Peng
Zhang, Mei-Ling
Pan, Juan
Guan, Wei
Li, Xiao-Mao
Yang, Bing-You
Kuang, Hai-Xue
author_sort Liu, Yan
collection PubMed
description Five new oleanane-type triterpenoid saponins (1–5), together with 24 known saponins (6–29) were isolated from the fruit of Acanthopanax senticosus. Their structures were determined by extensive spectroscopic analysis, including 1D, 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), in combination with chemical methods (acid hydrolysis). The neuroinflammation model was established by lipopolysaccharide (LPS)-induced BV2 microglia, and the neuroprotective effects of all compounds (1–29) were evaluated.
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spelling pubmed-88996142022-03-08 Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms Liu, Yan Jiang, Peng Zhang, Mei-Ling Pan, Juan Guan, Wei Li, Xiao-Mao Yang, Bing-You Kuang, Hai-Xue Front Chem Chemistry Five new oleanane-type triterpenoid saponins (1–5), together with 24 known saponins (6–29) were isolated from the fruit of Acanthopanax senticosus. Their structures were determined by extensive spectroscopic analysis, including 1D, 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), in combination with chemical methods (acid hydrolysis). The neuroinflammation model was established by lipopolysaccharide (LPS)-induced BV2 microglia, and the neuroprotective effects of all compounds (1–29) were evaluated. Frontiers Media S.A. 2022-02-21 /pmc/articles/PMC8899614/ /pubmed/35265584 http://dx.doi.org/10.3389/fchem.2022.825763 Text en Copyright © 2022 Liu, Jiang, Zhang, Pan, Guan, Li, Yang and Kuang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Liu, Yan
Jiang, Peng
Zhang, Mei-Ling
Pan, Juan
Guan, Wei
Li, Xiao-Mao
Yang, Bing-You
Kuang, Hai-Xue
Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms
title Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms
title_full Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms
title_fullStr Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms
title_full_unstemmed Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms
title_short Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms
title_sort triterpenoid saponins from the fruit of acanthopanax senticosus (rupr. & maxim.) harms
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899614/
https://www.ncbi.nlm.nih.gov/pubmed/35265584
http://dx.doi.org/10.3389/fchem.2022.825763
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