An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage

Piperacillin-tazobactam is a broad-spectrum antimicrobial agent that is commonly used in clinical practice. The development of delayed drug hypersensitivity reaction (DHR) has been reported in several cases previously. Here we describe an unusual case of non-immediate DHR due to a prolonged course o...

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Autores principales: Lv, Jiawen, Wu, Guannan, Zhang, Fang, Su, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899667/
https://www.ncbi.nlm.nih.gov/pubmed/33558219
http://dx.doi.org/10.1136/ejhpharm-2020-002575
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author Lv, Jiawen
Wu, Guannan
Zhang, Fang
Su, Xin
author_facet Lv, Jiawen
Wu, Guannan
Zhang, Fang
Su, Xin
author_sort Lv, Jiawen
collection PubMed
description Piperacillin-tazobactam is a broad-spectrum antimicrobial agent that is commonly used in clinical practice. The development of delayed drug hypersensitivity reaction (DHR) has been reported in several cases previously. Here we describe an unusual case of non-immediate DHR due to a prolonged course of piperacillin-tazobactam. We report a 22-year-old man who developed fever, eosinophilia, thrombocytopenia and elevated hepatic enzymes following 17 days of piperacillin-tazobactam for methicillin-sensitive Staphylococcus aureus (MSSA) pneumonia. These adverse reactions were reversed immediately after antibiotic cessation. Our case highlights that clinicians should be aware of delayed adverse effects in patients receiving long-term piperacillin-tazobactam treatment.
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spelling pubmed-88996672022-03-22 An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage Lv, Jiawen Wu, Guannan Zhang, Fang Su, Xin Eur J Hosp Pharm Case Report Piperacillin-tazobactam is a broad-spectrum antimicrobial agent that is commonly used in clinical practice. The development of delayed drug hypersensitivity reaction (DHR) has been reported in several cases previously. Here we describe an unusual case of non-immediate DHR due to a prolonged course of piperacillin-tazobactam. We report a 22-year-old man who developed fever, eosinophilia, thrombocytopenia and elevated hepatic enzymes following 17 days of piperacillin-tazobactam for methicillin-sensitive Staphylococcus aureus (MSSA) pneumonia. These adverse reactions were reversed immediately after antibiotic cessation. Our case highlights that clinicians should be aware of delayed adverse effects in patients receiving long-term piperacillin-tazobactam treatment. BMJ Publishing Group 2022-03 2021-02-08 /pmc/articles/PMC8899667/ /pubmed/33558219 http://dx.doi.org/10.1136/ejhpharm-2020-002575 Text en © European Association of Hospital Pharmacists 2022. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, an indication of whether changes were made, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Report
Lv, Jiawen
Wu, Guannan
Zhang, Fang
Su, Xin
An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
title An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
title_full An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
title_fullStr An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
title_full_unstemmed An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
title_short An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
title_sort unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899667/
https://www.ncbi.nlm.nih.gov/pubmed/33558219
http://dx.doi.org/10.1136/ejhpharm-2020-002575
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