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Maintenance and gene electrotransfer efficiency of antibiotic resistance gene-free plasmids encoding mouse, canine and human interleukin-12 orthologues

Interleukin 12 (IL-12) is a cytokine used as a therapeutic molecule in cancer immunotherapy. Gene electrotransfer mediated delivery of IL-12 gene has reached clinical evaluation in the USA using a plasmid that in addition to IL-12 gene also carry an antibiotic resistance gene needed for its producti...

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Detalles Bibliográficos
Autores principales:	Kamensek, Urska, Rencelj, Andrej, Jesenko, Tanja, Remic, Tinkara, Sersa, Gregor, Cemazar, Maja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899673/ https://www.ncbi.nlm.nih.gov/pubmed/35265755 http://dx.doi.org/10.1016/j.heliyon.2022.e08879

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