Cargando…

The Sec61 translocon is a therapeutic vulnerability in multiple myeloma

Multiple myeloma (MM) is an incurable malignancy characterized by the uncontrolled expansion of plasma cells in the bone marrow. While proteasome inhibitors like bortezomib efficiently halt MM progression, drug resistance inevitably develop, and novel therapeutic approaches are needed. Here, we used...

Descripción completa

Detalles Bibliográficos
Autores principales:	Domenger, Antoine, Choisy, Caroline, Baron, Ludivine, Mayau, Véronique, Perthame, Emeline, Deriano, Ludovic, Arnulf, Bertrand, Bories, Jean‐Christophe, Dadaglio, Gilles, Demangel, Caroline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899908/ https://www.ncbi.nlm.nih.gov/pubmed/35014767 http://dx.doi.org/10.15252/emmm.202114740

Ejemplares similares

Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma
por: Domenger, Antoine, et al.
Publicado: (2023)

Mycolactone subverts immunity by selectively blocking the Sec61 translocon
por: Baron, Ludivine, et al.
Publicado: (2016)

The Hydrophobic Core of the Sec61 Translocon Defines the Hydrophobicity Threshold for Membrane Integration
por: Junne, Tina, et al.
Publicado: (2010)

TRC40 can deliver short secretory proteins to the Sec61 translocon
por: Johnson, Nicholas, et al.
Publicado: (2012)

Cotranslational Folding Inhibits Translocation from Within the Ribosome–Sec61 Translocon Complex
por: Conti, Brian J., et al.
Publicado: (2014)

The Dynamic SecYEG Translocon
por: Oswald, Julia, et al.
Publicado: (2021)

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum
por: Alder, Nathan N., et al.
Publicado: (2005)

The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon
por: von der Malsburg, Karina, et al.
Publicado: (2015)

The Sec61 translocon limits IRE1α signaling during the unfolded protein response
por: Sundaram, Arunkumar, et al.
Publicado: (2017)

Copper inhibits protein maturation in the secretory pathway by targeting the Sec61 translocon in Saccharomyces cerevisiae
por: Saha, Nitu, et al.
Publicado: (2022)

Unlocking the Bacterial SecY Translocon
por: Corey, Robin A., et al.
Publicado: (2016)

Structure of the Inhibited State of the Sec Translocon
por: Gérard, Samuel F., et al.
Publicado: (2020)

Inhibition of the Sec61 translocon overcomes cytokine‐induced glucocorticoid resistance in T‐cell acute lymphoblastic leukaemia
por: Meyer, Lauren K., et al.
Publicado: (2022)

Sec61 complex/translocon: The role of an atypical ER Ca(2+)-leak channel in health and disease
por: Parys, Jan B., et al.
Publicado: (2022)

Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative
por: Pauwels, Eva, et al.
Publicado: (2023)

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
por: Zong, Guanghui, et al.
Publicado: (2019)

PKC Inhibits Sec61 Translocon-Mediated Sarcoplasmic Reticulum Ca(2+) Leak in Smooth Muscle Cells
por: Dagnino-Acosta, Adan, et al.
Publicado: (2022)

Architecture of the active post‐translational Sec translocon
por: Weng, Tsai‐Hsuan, et al.
Publicado: (2020)

The Bacterial Translocon SecYEG Opens upon Ribosome Binding
por: Knyazev, Denis G., et al.
Publicado: (2013)

SEC-Translocon Dependent Extracytoplasmic Proteins of Candidatus Liberibacter asiaticus
por: Prasad, Samiksha, et al.
Publicado: (2016)

Driving Forces of Translocation Through Bacterial Translocon SecYEG
por: Knyazev, Denis G., et al.
Publicado: (2018)

Mycolactone enhances the Ca(2+) leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca(2+) permeable state
por: Bhadra, Pratiti, et al.
Publicado: (2021)

The conformations and basal conformational dynamics of translocation factor SecDF vary with translocon SecYEG interaction
por: Weaver, D.R., et al.
Publicado: (2022)

Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ
por: Yu, Wei, et al.
Publicado: (2020)

Partially inserted nascent chain unzips the lateral gate of the Sec translocon
por: Kater, Lukas, et al.
Publicado: (2019)

Loopy Sec61 mutants
por: LeBrasseur, Nicole
Publicado: (2005)

Charge-driven dynamics of nascent chain movement through the SecYEG translocon
por: Ismail, Nurzian, et al.
Publicado: (2015)

Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis
por: Alvira, Sara, et al.
Publicado: (2020)

Structural determinants of a permeation barrier of the SecYEG translocon in the active state
por: Sobakinskaya, Ekaterina, et al.
Publicado: (2021)

Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex
por: Sicking, Mark, et al.
Publicado: (2021)

Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG–SecDF–YajC–YidC
por: Komar, Joanna, et al.
Publicado: (2016)

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62
por: Itskanov, Samuel, et al.
Publicado: (2021)

In vitro membrane protein synthesis inside Sec translocon-reconstituted cell-sized liposomes
por: Ohta, Naoki, et al.
Publicado: (2016)

Sec translocon has an insertase-like function in addition to polypeptide conduction through the channel
por: Ito, Koreaki, et al.
Publicado: (2019)

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity
por: Hall, Belinda S, et al.
Publicado: (2021)

HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon
por: Ahdash, Zainab, et al.
Publicado: (2019)

Sec61 in antigen cross-presentation
por: Zehner, Matthias, et al.
Publicado: (2015)

Role of the Cytoplasmic Segments of Sec61α in the Ribosome-Binding and Translocation-Promoting Activities of the Sec61 Complex
por: Raden, David, et al.
Publicado: (2000)

How does Sec63 affect the conformation of Sec61 in yeast?
por: Bhadra, Pratiti, et al.
Publicado: (2021)

Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
por: Linxweiler, Maximilian, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_01loi3t663ls8s347om7c2acq1