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Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis

Psoriasis is a complex chronic inflammatory skin disease with unclear molecular mechanisms. We found that the Src homology‐2 domain‐containing protein tyrosine phosphatase‐2 (SHP2) was highly expressed in both psoriatic patients and imiquimod (IMQ)‐induced psoriasis‐like mice. Also, the SHP2 alloste...

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Detalles Bibliográficos
Autores principales:	Zhu, Yuyu, Wu, Zhigui, Yan, Wei, Shao, Fenli, Ke, Bowen, Jiang, Xian, Gao, Jian, Guo, Wenjie, Lai, Yuping, Ma, Hongyue, Chen, Dijun, Xu, Qiang, Sun, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899919/ https://www.ncbi.nlm.nih.gov/pubmed/34936223 http://dx.doi.org/10.15252/emmm.202114455

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