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Microbiota medicine: towards clinical revolution
The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut microbiota. The normal flora is the site of many physiological functions such as enhancing the host immunity, participating in the nutrient absorption...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900094/ https://www.ncbi.nlm.nih.gov/pubmed/35255932 http://dx.doi.org/10.1186/s12967-022-03296-9 |
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author | Gebrayel, Prisca Nicco, Carole Al Khodor, Souhaila Bilinski, Jaroslaw Caselli, Elisabetta Comelli, Elena M. Egert, Markus Giaroni, Cristina Karpinski, Tomasz M. Loniewski, Igor Mulak, Agata Reygner, Julie Samczuk, Paulina Serino, Matteo Sikora, Mariusz Terranegra, Annalisa Ufnal, Marcin Villeger, Romain Pichon, Chantal Konturek, Peter Edeas, Marvin |
author_facet | Gebrayel, Prisca Nicco, Carole Al Khodor, Souhaila Bilinski, Jaroslaw Caselli, Elisabetta Comelli, Elena M. Egert, Markus Giaroni, Cristina Karpinski, Tomasz M. Loniewski, Igor Mulak, Agata Reygner, Julie Samczuk, Paulina Serino, Matteo Sikora, Mariusz Terranegra, Annalisa Ufnal, Marcin Villeger, Romain Pichon, Chantal Konturek, Peter Edeas, Marvin |
author_sort | Gebrayel, Prisca |
collection | PubMed |
description | The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut microbiota. The normal flora is the site of many physiological functions such as enhancing the host immunity, participating in the nutrient absorption and protecting the body against pathogenic microorganisms. Numerous investigations showed a bidirectional interplay between gut microbiota and many organs within the human body such as the intestines, the lungs, the brain, and the skin. Large body of evidence demonstrated, more than a decade ago, that the gut microbial alteration is a key factor in the pathogenesis of many local and systemic disorders. In this regard, a deep understanding of the mechanisms involved in the gut microbial symbiosis/dysbiosis is crucial for the clinical and health field. We review the most recent studies on the involvement of gut microbiota in the pathogenesis of many diseases. We also elaborate the different strategies used to manipulate the gut microbiota in the prevention and treatment of disorders. The future of medicine is strongly related to the quality of our microbiota. Targeting microbiota dysbiosis will be a huge challenge. |
format | Online Article Text |
id | pubmed-8900094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89000942022-03-07 Microbiota medicine: towards clinical revolution Gebrayel, Prisca Nicco, Carole Al Khodor, Souhaila Bilinski, Jaroslaw Caselli, Elisabetta Comelli, Elena M. Egert, Markus Giaroni, Cristina Karpinski, Tomasz M. Loniewski, Igor Mulak, Agata Reygner, Julie Samczuk, Paulina Serino, Matteo Sikora, Mariusz Terranegra, Annalisa Ufnal, Marcin Villeger, Romain Pichon, Chantal Konturek, Peter Edeas, Marvin J Transl Med Review The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut microbiota. The normal flora is the site of many physiological functions such as enhancing the host immunity, participating in the nutrient absorption and protecting the body against pathogenic microorganisms. Numerous investigations showed a bidirectional interplay between gut microbiota and many organs within the human body such as the intestines, the lungs, the brain, and the skin. Large body of evidence demonstrated, more than a decade ago, that the gut microbial alteration is a key factor in the pathogenesis of many local and systemic disorders. In this regard, a deep understanding of the mechanisms involved in the gut microbial symbiosis/dysbiosis is crucial for the clinical and health field. We review the most recent studies on the involvement of gut microbiota in the pathogenesis of many diseases. We also elaborate the different strategies used to manipulate the gut microbiota in the prevention and treatment of disorders. The future of medicine is strongly related to the quality of our microbiota. Targeting microbiota dysbiosis will be a huge challenge. BioMed Central 2022-03-07 /pmc/articles/PMC8900094/ /pubmed/35255932 http://dx.doi.org/10.1186/s12967-022-03296-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Gebrayel, Prisca Nicco, Carole Al Khodor, Souhaila Bilinski, Jaroslaw Caselli, Elisabetta Comelli, Elena M. Egert, Markus Giaroni, Cristina Karpinski, Tomasz M. Loniewski, Igor Mulak, Agata Reygner, Julie Samczuk, Paulina Serino, Matteo Sikora, Mariusz Terranegra, Annalisa Ufnal, Marcin Villeger, Romain Pichon, Chantal Konturek, Peter Edeas, Marvin Microbiota medicine: towards clinical revolution |
title | Microbiota medicine: towards clinical revolution |
title_full | Microbiota medicine: towards clinical revolution |
title_fullStr | Microbiota medicine: towards clinical revolution |
title_full_unstemmed | Microbiota medicine: towards clinical revolution |
title_short | Microbiota medicine: towards clinical revolution |
title_sort | microbiota medicine: towards clinical revolution |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900094/ https://www.ncbi.nlm.nih.gov/pubmed/35255932 http://dx.doi.org/10.1186/s12967-022-03296-9 |
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