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Safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (IMP) produced by Corynebacterium stationis KCCM 80235 for all animal species (CJ Europe GmbH)

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of disodium 5’‐inosinate (IMP) produced by fermentation using Corynebacterium stationis KCCM 80235 as a sensory additive (flavouring compound) in feed and water for drinking fo...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Fašmon Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Anguita, Montserrat, Brozzi, Rosella, Galobart, Jaume, Manini, Paola, Tarrés‐Call, Jordi, Pettenati, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900116/
https://www.ncbi.nlm.nih.gov/pubmed/35281652
http://dx.doi.org/10.2903/j.efsa.2022.7153
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Manini, Paola
Tarrés‐Call, Jordi
Pettenati, Elisa
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Manini, Paola
Tarrés‐Call, Jordi
Pettenati, Elisa
collection PubMed
description Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of disodium 5’‐inosinate (IMP) produced by fermentation using Corynebacterium stationis KCCM 80235 as a sensory additive (flavouring compound) in feed and water for drinking for all animal species. The production strain is genetically modified, and it is resistant to streptomycin. No viable cells were detected in the final product. However, uncertainties remained on the genetic basis of the streptomycin resistance and on the possible presence of recombinant DNA from the production strain in the final product. Therefore, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the safety of the additive for the target species, consumers, users and the environment. Moreover, the FEEDAP Panel reiterated its previous concerns on the safety of the use of IMP in water for drinking due to hygienic reasons. The Panel concluded that the additive is efficacious to contribute to the flavour of feed and water for drinking.
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spelling pubmed-89001162022-03-11 Safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (IMP) produced by Corynebacterium stationis KCCM 80235 for all animal species (CJ Europe GmbH) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Anguita, Montserrat Brozzi, Rosella Galobart, Jaume Manini, Paola Tarrés‐Call, Jordi Pettenati, Elisa EFSA J Scientific Opinion Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of disodium 5’‐inosinate (IMP) produced by fermentation using Corynebacterium stationis KCCM 80235 as a sensory additive (flavouring compound) in feed and water for drinking for all animal species. The production strain is genetically modified, and it is resistant to streptomycin. No viable cells were detected in the final product. However, uncertainties remained on the genetic basis of the streptomycin resistance and on the possible presence of recombinant DNA from the production strain in the final product. Therefore, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the safety of the additive for the target species, consumers, users and the environment. Moreover, the FEEDAP Panel reiterated its previous concerns on the safety of the use of IMP in water for drinking due to hygienic reasons. The Panel concluded that the additive is efficacious to contribute to the flavour of feed and water for drinking. John Wiley and Sons Inc. 2022-03-07 /pmc/articles/PMC8900116/ /pubmed/35281652 http://dx.doi.org/10.2903/j.efsa.2022.7153 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Manini, Paola
Tarrés‐Call, Jordi
Pettenati, Elisa
Safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (IMP) produced by Corynebacterium stationis KCCM 80235 for all animal species (CJ Europe GmbH)
title Safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (IMP) produced by Corynebacterium stationis KCCM 80235 for all animal species (CJ Europe GmbH)
title_full Safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (IMP) produced by Corynebacterium stationis KCCM 80235 for all animal species (CJ Europe GmbH)
title_fullStr Safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (IMP) produced by Corynebacterium stationis KCCM 80235 for all animal species (CJ Europe GmbH)
title_full_unstemmed Safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (IMP) produced by Corynebacterium stationis KCCM 80235 for all animal species (CJ Europe GmbH)
title_short Safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (IMP) produced by Corynebacterium stationis KCCM 80235 for all animal species (CJ Europe GmbH)
title_sort safety and efficacy of a feed additive consisting of disodium 5'‐inosinate (imp) produced by corynebacterium stationis kccm 80235 for all animal species (cj europe gmbh)
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900116/
https://www.ncbi.nlm.nih.gov/pubmed/35281652
http://dx.doi.org/10.2903/j.efsa.2022.7153
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