Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin

Hormonal factors affecting the vascular adaptions of the uteroplacental unit in noncomplicated and complicated pregnancies are of interest. Here, 4 human placentas from women with and without preeclampsia (PE) were investigated for the presence of placental lactogen (PL)-derived, antiangiogenic vaso...

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Autores principales: Markl-Hahn, Hülya, Neugebauer, Leon, Lenke, Livia, Ecker, Sarah, Merz, Tamara, McCook, Oscar, Khoder, Noura, Brucker, Cosima, Radermacher, Peter, Waller, Christiane, Clapp, Carmen, Bertsch, Thomas, Triebel, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900287/
https://www.ncbi.nlm.nih.gov/pubmed/35265784
http://dx.doi.org/10.1210/jendso/bvac029
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author Markl-Hahn, Hülya
Neugebauer, Leon
Lenke, Livia
Ecker, Sarah
Merz, Tamara
McCook, Oscar
Khoder, Noura
Brucker, Cosima
Radermacher, Peter
Waller, Christiane
Clapp, Carmen
Bertsch, Thomas
Triebel, Jakob
author_facet Markl-Hahn, Hülya
Neugebauer, Leon
Lenke, Livia
Ecker, Sarah
Merz, Tamara
McCook, Oscar
Khoder, Noura
Brucker, Cosima
Radermacher, Peter
Waller, Christiane
Clapp, Carmen
Bertsch, Thomas
Triebel, Jakob
author_sort Markl-Hahn, Hülya
collection PubMed
description Hormonal factors affecting the vascular adaptions of the uteroplacental unit in noncomplicated and complicated pregnancies are of interest. Here, 4 human placentas from women with and without preeclampsia (PE) were investigated for the presence of placental lactogen (PL)-derived, antiangiogenic vasoinhibin. Western blotting and mass spectrometry of placental tissue revealed the presence of a 9-kDa PL-derived vasoinhibin, the normal 22-kDa full-length PL, and a 28-kDa immunoreactive protein of undetermined nature. The sequence of the 9-kDa vasoinhibin includes the antiangiogenic determinant of vasoinhibin and could constitute a relevant factor in normal pregnancy and PE.
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spelling pubmed-89002872022-03-08 Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin Markl-Hahn, Hülya Neugebauer, Leon Lenke, Livia Ecker, Sarah Merz, Tamara McCook, Oscar Khoder, Noura Brucker, Cosima Radermacher, Peter Waller, Christiane Clapp, Carmen Bertsch, Thomas Triebel, Jakob J Endocr Soc Brief Report Hormonal factors affecting the vascular adaptions of the uteroplacental unit in noncomplicated and complicated pregnancies are of interest. Here, 4 human placentas from women with and without preeclampsia (PE) were investigated for the presence of placental lactogen (PL)-derived, antiangiogenic vasoinhibin. Western blotting and mass spectrometry of placental tissue revealed the presence of a 9-kDa PL-derived vasoinhibin, the normal 22-kDa full-length PL, and a 28-kDa immunoreactive protein of undetermined nature. The sequence of the 9-kDa vasoinhibin includes the antiangiogenic determinant of vasoinhibin and could constitute a relevant factor in normal pregnancy and PE. Oxford University Press 2022-02-20 /pmc/articles/PMC8900287/ /pubmed/35265784 http://dx.doi.org/10.1210/jendso/bvac029 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Markl-Hahn, Hülya
Neugebauer, Leon
Lenke, Livia
Ecker, Sarah
Merz, Tamara
McCook, Oscar
Khoder, Noura
Brucker, Cosima
Radermacher, Peter
Waller, Christiane
Clapp, Carmen
Bertsch, Thomas
Triebel, Jakob
Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin
title Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin
title_full Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin
title_fullStr Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin
title_full_unstemmed Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin
title_short Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin
title_sort human placental tissue contains a placental lactogen–derived vasoinhibin
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900287/
https://www.ncbi.nlm.nih.gov/pubmed/35265784
http://dx.doi.org/10.1210/jendso/bvac029
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