Genetic susceptibility to hereditary non-medullary thyroid cancer

Non-medullary thyroid cancer (NMTC) is the most common type of thyroid cancer. With the increasing incidence of NMTC in recent years, the familial form of the disease has also become more common than previously reported, accounting for 5–15% of NMTC cases. Familial NMTC is further classified as non-...

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Autores principales: Kamani, Tina, Charkhchi, Parsa, Zahedi, Afshan, Akbari, Mohammad R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900298/
https://www.ncbi.nlm.nih.gov/pubmed/35255942
http://dx.doi.org/10.1186/s13053-022-00215-3
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author Kamani, Tina
Charkhchi, Parsa
Zahedi, Afshan
Akbari, Mohammad R.
author_facet Kamani, Tina
Charkhchi, Parsa
Zahedi, Afshan
Akbari, Mohammad R.
author_sort Kamani, Tina
collection PubMed
description Non-medullary thyroid cancer (NMTC) is the most common type of thyroid cancer. With the increasing incidence of NMTC in recent years, the familial form of the disease has also become more common than previously reported, accounting for 5–15% of NMTC cases. Familial NMTC is further classified as non-syndromic and the less common syndromic FNMTC. Although syndromic NMTC has well-known genetic risk factors, the gene(s) responsible for the vast majority of non-syndromic FNMTC cases are yet to be identified. To date, several candidate genes have been identified as susceptibility genes in hereditary NMTC. This review summarizes genetic predisposition to non-medullary thyroid cancer and expands on the role of genetic variants in thyroid cancer tumorigenesis and the level of penetrance of NMTC-susceptibility genes.
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spelling pubmed-89002982022-03-17 Genetic susceptibility to hereditary non-medullary thyroid cancer Kamani, Tina Charkhchi, Parsa Zahedi, Afshan Akbari, Mohammad R. Hered Cancer Clin Pract Review Non-medullary thyroid cancer (NMTC) is the most common type of thyroid cancer. With the increasing incidence of NMTC in recent years, the familial form of the disease has also become more common than previously reported, accounting for 5–15% of NMTC cases. Familial NMTC is further classified as non-syndromic and the less common syndromic FNMTC. Although syndromic NMTC has well-known genetic risk factors, the gene(s) responsible for the vast majority of non-syndromic FNMTC cases are yet to be identified. To date, several candidate genes have been identified as susceptibility genes in hereditary NMTC. This review summarizes genetic predisposition to non-medullary thyroid cancer and expands on the role of genetic variants in thyroid cancer tumorigenesis and the level of penetrance of NMTC-susceptibility genes. BioMed Central 2022-03-07 /pmc/articles/PMC8900298/ /pubmed/35255942 http://dx.doi.org/10.1186/s13053-022-00215-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Kamani, Tina
Charkhchi, Parsa
Zahedi, Afshan
Akbari, Mohammad R.
Genetic susceptibility to hereditary non-medullary thyroid cancer
title Genetic susceptibility to hereditary non-medullary thyroid cancer
title_full Genetic susceptibility to hereditary non-medullary thyroid cancer
title_fullStr Genetic susceptibility to hereditary non-medullary thyroid cancer
title_full_unstemmed Genetic susceptibility to hereditary non-medullary thyroid cancer
title_short Genetic susceptibility to hereditary non-medullary thyroid cancer
title_sort genetic susceptibility to hereditary non-medullary thyroid cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900298/
https://www.ncbi.nlm.nih.gov/pubmed/35255942
http://dx.doi.org/10.1186/s13053-022-00215-3
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