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Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson’s disease models in vitro and vivo

PURPOSE: Parkinson's disease (PD) is the second most common neurodegenerative disease without cure or effective treatment. This study explores whether the yeast internal NADH-quinone oxidoreductase (NDI1) can functionally replace the defective mammalian mitochondrial complex I, which may provid...

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Detalles Bibliográficos
Autores principales:	Li, Hongzhi, Sun, Bohao, Huang, Yuting, Zhang, Jing, Xu, Xuejing, Shen, Yuqi, Chen, Zhuo, Yang, Jifeng, Shen, Luxi, Hu, Yongwu, Gu, Haihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900322/ https://www.ncbi.nlm.nih.gov/pubmed/35255803 http://dx.doi.org/10.1186/s10020-022-00456-x

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