Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications

Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells and virus-infected cells. NK cells also play an important role in the graft versus leukemia response. However, they can over-develop inflammatory reactions by secreting inflammatory cytokines and increasi...

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Autores principales: Abbasi, Batol, Shamsasenjan, Karim, Ahmadi, Majid, Beheshti, Seyedeh Ameneh, Saleh, Mahshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900412/
https://www.ncbi.nlm.nih.gov/pubmed/35255980
http://dx.doi.org/10.1186/s13287-022-02777-4
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author Abbasi, Batol
Shamsasenjan, Karim
Ahmadi, Majid
Beheshti, Seyedeh Ameneh
Saleh, Mahshid
author_facet Abbasi, Batol
Shamsasenjan, Karim
Ahmadi, Majid
Beheshti, Seyedeh Ameneh
Saleh, Mahshid
author_sort Abbasi, Batol
collection PubMed
description Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells and virus-infected cells. NK cells also play an important role in the graft versus leukemia response. However, they can over-develop inflammatory reactions by secreting inflammatory cytokines and increasing Th1 differentiation, eventually leading to tissue damage. Today, researchers have attributed some autoimmune diseases and GVHD to NK cells. On the other hand, it has been shown that mesenchymal stem cells (MSCs) can modulate the activity of NK cells, while some researchers have shown that NK cells can cause MSCs to lysis. Therefore, we considered it is necessary to investigate the effect of these two cells and their signaling pathway in contact with each other, also their clinical applications.
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spelling pubmed-89004122022-03-17 Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications Abbasi, Batol Shamsasenjan, Karim Ahmadi, Majid Beheshti, Seyedeh Ameneh Saleh, Mahshid Stem Cell Res Ther Review Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells and virus-infected cells. NK cells also play an important role in the graft versus leukemia response. However, they can over-develop inflammatory reactions by secreting inflammatory cytokines and increasing Th1 differentiation, eventually leading to tissue damage. Today, researchers have attributed some autoimmune diseases and GVHD to NK cells. On the other hand, it has been shown that mesenchymal stem cells (MSCs) can modulate the activity of NK cells, while some researchers have shown that NK cells can cause MSCs to lysis. Therefore, we considered it is necessary to investigate the effect of these two cells and their signaling pathway in contact with each other, also their clinical applications. BioMed Central 2022-03-07 /pmc/articles/PMC8900412/ /pubmed/35255980 http://dx.doi.org/10.1186/s13287-022-02777-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Abbasi, Batol
Shamsasenjan, Karim
Ahmadi, Majid
Beheshti, Seyedeh Ameneh
Saleh, Mahshid
Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
title Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
title_full Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
title_fullStr Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
title_full_unstemmed Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
title_short Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
title_sort mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900412/
https://www.ncbi.nlm.nih.gov/pubmed/35255980
http://dx.doi.org/10.1186/s13287-022-02777-4
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