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Animal models in compartment syndrome: a review of existing literature
OBJECTIVE: Extremity compartment syndrome (ECS) is a morbid condition resulting in permanent myoneural damage. Currently, the diagnosis of compartment syndrome relies on clinical symptoms and/or intracompartment pressure measurements, both of which are poor predictors of ECS. Animal models have been...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900462/ https://www.ncbi.nlm.nih.gov/pubmed/35282390 http://dx.doi.org/10.1097/OI9.0000000000000163 |
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author | O’Neill, Dillon C. Boes, Emily A. McCutcheon, Chance Haller, Justin M. |
author_facet | O’Neill, Dillon C. Boes, Emily A. McCutcheon, Chance Haller, Justin M. |
author_sort | O’Neill, Dillon C. |
collection | PubMed |
description | OBJECTIVE: Extremity compartment syndrome (ECS) is a morbid condition resulting in permanent myoneural damage. Currently, the diagnosis of compartment syndrome relies on clinical symptoms and/or intracompartment pressure measurements, both of which are poor predictors of ECS. Animal models have been used to better define cellular mechanisms, diagnosis, and treatment of ECS. However, no standardized model exists. The purpose of this study was to identify existing animal research on extremity compartment syndrome to summarize the current state of the literature and to identify weaknesses that could be improved with additional research. METHODS: A MEDLINE database search and reverse inclusion protocol were utilized. We included all animal models of ECS. RESULTS: Forty-one studies were included. Dogs were the most commonly used model species, followed by pigs and rats. Most studies sought to better define the pathophysiology of compartment syndrome. Other studies evaluated experimental diagnostic modalities or potential treatments. The most common compartment syndrome model was intracompartment infusion, followed by tourniquet and intracompartment balloon models. Few models incorporated additional soft tissue or osseous injury. Only 65.9% of the reviewed studies confirmed that their model created myoneural injury similar to extremity compartment syndrome. CONCLUSIONS: Study purpose, methodology, and outcome measures varied widely across included studies. A standardized definition for animal compartment syndrome would direct more consistent research in this field. Few animal models have investigated the pathophysiologic relationship between traumatic injury and the development of compartment syndrome. A validated, clinically relevant animal model of extremity compartment syndrome would spur improvement in diagnosis and therapeutic interventions. |
format | Online Article Text |
id | pubmed-8900462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-89004622022-03-10 Animal models in compartment syndrome: a review of existing literature O’Neill, Dillon C. Boes, Emily A. McCutcheon, Chance Haller, Justin M. OTA Int Meeting Proceedings OBJECTIVE: Extremity compartment syndrome (ECS) is a morbid condition resulting in permanent myoneural damage. Currently, the diagnosis of compartment syndrome relies on clinical symptoms and/or intracompartment pressure measurements, both of which are poor predictors of ECS. Animal models have been used to better define cellular mechanisms, diagnosis, and treatment of ECS. However, no standardized model exists. The purpose of this study was to identify existing animal research on extremity compartment syndrome to summarize the current state of the literature and to identify weaknesses that could be improved with additional research. METHODS: A MEDLINE database search and reverse inclusion protocol were utilized. We included all animal models of ECS. RESULTS: Forty-one studies were included. Dogs were the most commonly used model species, followed by pigs and rats. Most studies sought to better define the pathophysiology of compartment syndrome. Other studies evaluated experimental diagnostic modalities or potential treatments. The most common compartment syndrome model was intracompartment infusion, followed by tourniquet and intracompartment balloon models. Few models incorporated additional soft tissue or osseous injury. Only 65.9% of the reviewed studies confirmed that their model created myoneural injury similar to extremity compartment syndrome. CONCLUSIONS: Study purpose, methodology, and outcome measures varied widely across included studies. A standardized definition for animal compartment syndrome would direct more consistent research in this field. Few animal models have investigated the pathophysiologic relationship between traumatic injury and the development of compartment syndrome. A validated, clinically relevant animal model of extremity compartment syndrome would spur improvement in diagnosis and therapeutic interventions. Lippincott Williams & Wilkins 2022-03-10 /pmc/articles/PMC8900462/ /pubmed/35282390 http://dx.doi.org/10.1097/OI9.0000000000000163 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Orthopaedic Trauma Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Meeting Proceedings O’Neill, Dillon C. Boes, Emily A. McCutcheon, Chance Haller, Justin M. Animal models in compartment syndrome: a review of existing literature |
title | Animal models in compartment syndrome: a review of existing literature |
title_full | Animal models in compartment syndrome: a review of existing literature |
title_fullStr | Animal models in compartment syndrome: a review of existing literature |
title_full_unstemmed | Animal models in compartment syndrome: a review of existing literature |
title_short | Animal models in compartment syndrome: a review of existing literature |
title_sort | animal models in compartment syndrome: a review of existing literature |
topic | Meeting Proceedings |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900462/ https://www.ncbi.nlm.nih.gov/pubmed/35282390 http://dx.doi.org/10.1097/OI9.0000000000000163 |
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