Ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids

The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo­propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb­­oxy­lic acid], a fluoro­quinolone anti­biotic, namely, ciprofloxacin 2,6-di­hydroxy­benzoate salt, C(17)H(19)FN(3)O(3) (+)·C(7)H(5)O(4) (−), (I),...

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Autores principales: Nugraha, Yuda Prasetya, Sugiyama, Haruki, Uekusa, Hidehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900500/
https://www.ncbi.nlm.nih.gov/pubmed/35371545
http://dx.doi.org/10.1107/S2056989022001177
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author Nugraha, Yuda Prasetya
Sugiyama, Haruki
Uekusa, Hidehiro
author_facet Nugraha, Yuda Prasetya
Sugiyama, Haruki
Uekusa, Hidehiro
author_sort Nugraha, Yuda Prasetya
collection PubMed
description The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo­propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb­­oxy­lic acid], a fluoro­quinolone anti­biotic, namely, ciprofloxacin 2,6-di­hydroxy­benzoate salt, C(17)H(19)FN(3)O(3) (+)·C(7)H(5)O(4) (−), (I), and ciprofloxacin hydro­chloride–3,5-di­hydroxy­benzoic–water (1/1/1), C(17)H(19)FN(3)O(3) (+)·Cl(−)·C(7)H(6)O(4)·H(2)O, (II), were determined. In (I) and (II), the ciprofloxacin cations are connected via head-to-tail N—H⋯O hydrogen bonding. Both structures show an alternating layered arrangement between ciprofloxacin and di­hydroxy­benzoic acid.
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spelling pubmed-89005002022-03-31 Ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids Nugraha, Yuda Prasetya Sugiyama, Haruki Uekusa, Hidehiro Acta Crystallogr E Crystallogr Commun Research Communications The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo­propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb­­oxy­lic acid], a fluoro­quinolone anti­biotic, namely, ciprofloxacin 2,6-di­hydroxy­benzoate salt, C(17)H(19)FN(3)O(3) (+)·C(7)H(5)O(4) (−), (I), and ciprofloxacin hydro­chloride–3,5-di­hydroxy­benzoic–water (1/1/1), C(17)H(19)FN(3)O(3) (+)·Cl(−)·C(7)H(6)O(4)·H(2)O, (II), were determined. In (I) and (II), the ciprofloxacin cations are connected via head-to-tail N—H⋯O hydrogen bonding. Both structures show an alternating layered arrangement between ciprofloxacin and di­hydroxy­benzoic acid. International Union of Crystallography 2022-02-03 /pmc/articles/PMC8900500/ /pubmed/35371545 http://dx.doi.org/10.1107/S2056989022001177 Text en © Nugraha et al. 2022 https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Communications
Nugraha, Yuda Prasetya
Sugiyama, Haruki
Uekusa, Hidehiro
Ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids
title Ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids
title_full Ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids
title_fullStr Ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids
title_full_unstemmed Ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids
title_short Ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids
title_sort ciprofloxacin salt and salt co-crystal with di­hydroxy­benzoic acids
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900500/
https://www.ncbi.nlm.nih.gov/pubmed/35371545
http://dx.doi.org/10.1107/S2056989022001177
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