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COVID-19, liver dysfunction and pathophysiology: A conceptual discussion
The intra and extracellular pathways of hepatic injury by coronavirus disease 2019 (COVID-19) are still being studied. Understanding them is important to treat this viral disease and other liver and biliary tract disorders. Thus, this paper aims to present three hypotheses about liver injury caused...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900549/ https://www.ncbi.nlm.nih.gov/pubmed/35317425 http://dx.doi.org/10.3748/wjg.v28.i6.683 |
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author | Gonçalves Júnior, Jucier |
author_facet | Gonçalves Júnior, Jucier |
author_sort | Gonçalves Júnior, Jucier |
collection | PubMed |
description | The intra and extracellular pathways of hepatic injury by coronavirus disease 2019 (COVID-19) are still being studied. Understanding them is important to treat this viral disease and other liver and biliary tract disorders. Thus, this paper aims to present three hypotheses about liver injury caused by COVID-19: (1) The interactions between severe acute respiratory syndrome coronavirus 2 spike protein and membrane receptors in the hepatocyte; (2) The dysbiosis and “gut-liver axis” disruption in patients with serious clinical presentations of COVID-19; and (3) The inflammatory response exacerbated through the production of interleukins such as interleukin-6. However, despite these new perspectives, the pathophysiological process of liver injury caused by COVID-19 is still complex and multifactorial. Thus, understanding all these variables is a challenge to science but also the key to propose individualized and effective patient therapies. |
format | Online Article Text |
id | pubmed-8900549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-89005492022-03-21 COVID-19, liver dysfunction and pathophysiology: A conceptual discussion Gonçalves Júnior, Jucier World J Gastroenterol Letter to the Editor The intra and extracellular pathways of hepatic injury by coronavirus disease 2019 (COVID-19) are still being studied. Understanding them is important to treat this viral disease and other liver and biliary tract disorders. Thus, this paper aims to present three hypotheses about liver injury caused by COVID-19: (1) The interactions between severe acute respiratory syndrome coronavirus 2 spike protein and membrane receptors in the hepatocyte; (2) The dysbiosis and “gut-liver axis” disruption in patients with serious clinical presentations of COVID-19; and (3) The inflammatory response exacerbated through the production of interleukins such as interleukin-6. However, despite these new perspectives, the pathophysiological process of liver injury caused by COVID-19 is still complex and multifactorial. Thus, understanding all these variables is a challenge to science but also the key to propose individualized and effective patient therapies. Baishideng Publishing Group Inc 2022-02-14 2022-02-14 /pmc/articles/PMC8900549/ /pubmed/35317425 http://dx.doi.org/10.3748/wjg.v28.i6.683 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Letter to the Editor Gonçalves Júnior, Jucier COVID-19, liver dysfunction and pathophysiology: A conceptual discussion |
title | COVID-19, liver dysfunction and pathophysiology: A conceptual discussion |
title_full | COVID-19, liver dysfunction and pathophysiology: A conceptual discussion |
title_fullStr | COVID-19, liver dysfunction and pathophysiology: A conceptual discussion |
title_full_unstemmed | COVID-19, liver dysfunction and pathophysiology: A conceptual discussion |
title_short | COVID-19, liver dysfunction and pathophysiology: A conceptual discussion |
title_sort | covid-19, liver dysfunction and pathophysiology: a conceptual discussion |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900549/ https://www.ncbi.nlm.nih.gov/pubmed/35317425 http://dx.doi.org/10.3748/wjg.v28.i6.683 |
work_keys_str_mv | AT goncalvesjuniorjucier covid19liverdysfunctionandpathophysiologyaconceptualdiscussion |