Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation

Despite their widespread use in research, there has not yet been a systematic genomic analysis of human embryonic stem cell (hESC) lines at a single-nucleotide resolution. We therefore performed whole-genome sequencing (WGS) of 143 hESC lines and annotated their single-nucleotide and structural gene...

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Detalles Bibliográficos
Autores principales: Merkle, Florian T., Ghosh, Sulagna, Genovese, Giulio, Handsaker, Robert E., Kashin, Seva, Meyer, Daniel, Karczewski, Konrad J., O’Dushlaine, Colm, Pato, Carlos, Pato, Michele, MacArthur, Daniel G., McCarroll, Steven A., Eggan, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900618/
https://www.ncbi.nlm.nih.gov/pubmed/35176222
http://dx.doi.org/10.1016/j.stem.2022.01.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900618/
https://www.ncbi.nlm.nih.gov/pubmed/35176222
http://dx.doi.org/10.1016/j.stem.2022.01.011

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