Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

Chimeric antigen receptor T cell (CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and a...

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Autores principales: Li, Hongjun, Wang, Zejun, Ogunnaike, Edikan A, Wu, Qing, Chen, Guojun, Hu, Quanyin, Ci, Tianyuan, Chen, Zhaowei, Wang, Jinqiang, Wen, Di, Du, Hongwei, Jiang, Jie, Sun, Jie, Zhang, Xingcai, Dotti, Gianpietro, Gu, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RESEARCH ARTICLE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900686/
https://www.ncbi.nlm.nih.gov/pubmed/35265340
http://dx.doi.org/10.1093/nsr/nwab172
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author Li, Hongjun
Wang, Zejun
Ogunnaike, Edikan A
Wu, Qing
Chen, Guojun
Hu, Quanyin
Ci, Tianyuan
Chen, Zhaowei
Wang, Jinqiang
Wen, Di
Du, Hongwei
Jiang, Jie
Sun, Jie
Zhang, Xingcai
Dotti, Gianpietro
Gu, Zhen
author_facet Li, Hongjun
Wang, Zejun
Ogunnaike, Edikan A
Wu, Qing
Chen, Guojun
Hu, Quanyin
Ci, Tianyuan
Chen, Zhaowei
Wang, Jinqiang
Wen, Di
Du, Hongwei
Jiang, Jie
Sun, Jie
Zhang, Xingcai
Dotti, Gianpietro
Gu, Zhen
author_sort Li, Hongjun
collection PubMed
description Chimeric antigen receptor T cell (CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors.
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spelling pubmed-89006862022-03-08 Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy Li, Hongjun Wang, Zejun Ogunnaike, Edikan A Wu, Qing Chen, Guojun Hu, Quanyin Ci, Tianyuan Chen, Zhaowei Wang, Jinqiang Wen, Di Du, Hongwei Jiang, Jie Sun, Jie Zhang, Xingcai Dotti, Gianpietro Gu, Zhen Natl Sci Rev RESEARCH ARTICLE Chimeric antigen receptor T cell (CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors. Oxford University Press 2021-09-21 /pmc/articles/PMC8900686/ /pubmed/35265340 http://dx.doi.org/10.1093/nsr/nwab172 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLE
Li, Hongjun
Wang, Zejun
Ogunnaike, Edikan A
Wu, Qing
Chen, Guojun
Hu, Quanyin
Ci, Tianyuan
Chen, Zhaowei
Wang, Jinqiang
Wen, Di
Du, Hongwei
Jiang, Jie
Sun, Jie
Zhang, Xingcai
Dotti, Gianpietro
Gu, Zhen
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
title Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
title_full Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
title_fullStr Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
title_full_unstemmed Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
title_short Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
title_sort scattered seeding of car t cells in solid tumors augments anticancer efficacy
topic RESEARCH ARTICLE
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900686/
https://www.ncbi.nlm.nih.gov/pubmed/35265340
http://dx.doi.org/10.1093/nsr/nwab172
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