Cargando…

6-Phosphogluconate dehydrogenase and its crystal structures

6-Phosphogluconate dehydrogenase (6PGDH; EC 1.1.1.44) catalyses the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate in the context of the oxidative part of the pentose phosphate pathway. Depending on the species, it can be a homodimer or a homotetramer. Oligomerization plays...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hanau, Stefania, Helliwell, John R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2022
Materias:	Topical Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900737/ https://www.ncbi.nlm.nih.gov/pubmed/35234135 http://dx.doi.org/10.1107/S2053230X22001091

Ejemplares similares

Crystal Structures of 6-Phosphogluconate Dehydrogenase from Corynebacterium glutamicum
por: Yu, Hyeonjeong, et al.
Publicado: (2023)

Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate
por: Cameron, Scott, et al.
Publicado: (2009)

Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1
por: He, Weiwei, et al.
Publicado: (2007)

The crystal structures of the enzyme hydroxymethylbilane synthase, also known as porphobilinogen deaminase
por: Helliwell, John R.
Publicado: (2021)

Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase, phosphoglucomutase and lactate dehydrogenase in uterine cancer.
por: Marshall, M. J., et al.
Publicado: (1979)

Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase
por: Ruda, Gian Filippo, et al.
Publicado: (2010)

In Silico Analysis of Arabidopsis thaliana Peroxisomal 6-Phosphogluconate Dehydrogenase
por: Fernández-Fernández, Álvaro D., et al.
Publicado: (2016)

Origins of a cyanobacterial 6-phosphogluconate dehydrogenase in plastid-lacking eukaryotes
por: Maruyama, Shinichiro, et al.
Publicado: (2008)

Chloroplast-localized 6-phosphogluconate dehydrogenase is critical for maize endosperm starch accumulation
por: Spielbauer, Gertraud, et al.
Publicado: (2013)

Identification of Lignan Compounds as New 6-Phosphogluconate Dehydrogenase Inhibitors for Lung Cancer
por: Khan, Gul Bushra, et al.
Publicado: (2022)

Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer
por: Zheng, Wujian, et al.
Publicado: (2017)

Coenzyme Engineering of a Hyperthermophilic 6-Phosphogluconate Dehydrogenase from NADP(+) to NAD(+) with Its Application to Biobatteries
por: Chen, Hui, et al.
Publicado: (2016)

GLUCOSE-6-PHOSPHATE AND 6-PHOSPHOGLUCONATE DEHYDROGENASES FROM EGGS OF THE SEA URCHIN, ARBACIA PUNCTULATA
por: Krahl, M. E., et al.
Publicado: (1955)

Phosphogluconate dehydrogenase is a predictive biomarker for immunotherapy in hepatocellular carcinoma
por: Liu, Tiantian, et al.
Publicado: (2022)

Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
por: Liu, Ruilong, et al.
Publicado: (2019)

Non-AUG Translation Initiation Generates Peroxisomal Isoforms of 6-Phosphogluconate Dehydrogenase in Fungi
por: Kremp, Marco, et al.
Publicado: (2020)

Overexpression and simple purification of the Thermotoga maritima 6-phosphogluconate dehydrogenase in Escherichia coli and its application for NADPH regeneration
por: Wang, Yiran, et al.
Publicado: (2009)

Implications of differential peroxyl radical-induced inactivation of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase for the pentose phosphate pathway
por: Reyes, Juan Sebastián, et al.
Publicado: (2022)

6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function
por: Daneshmandi, Saeed, et al.
Publicado: (2021)

Overexpression of a Cytosolic 6-Phosphogluconate Dehydrogenase Gene Enhances the Resistance of Rice to Nilaparvata lugens
por: Chen, Lin, et al.
Publicado: (2020)

Enzymatic Synthesis of 2-Keto-3-Deoxy-6-Phosphogluconate by the 6-Phosphogluconate-Dehydratase From Caulobacter crescentus
por: Krevet, Sabine, et al.
Publicado: (2020)

Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to anti-malarial agent dihydroartemisinin
por: Elf, Shannon, et al.
Publicado: (2016)

Corrigendum: Enzymatic Synthesis of 2-Keto-3-Deoxy-6-Phosphogluconate by the 6-Phosphogluconate-Dehydratase From Caulobacter crescentus
por: Krevet, Sabine, et al.
Publicado: (2020)

High-Throughput Screening of Coenzyme Preference Change of Thermophilic 6-Phosphogluconate Dehydrogenase from NADP(+) to NAD(+)
por: Huang, Rui, et al.
Publicado: (2016)

Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function
por: Daneshmandi, Saeed, et al.
Publicado: (2021)

Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment
por: Berneburg, Isabell, et al.
Publicado: (2023)

Enzymatic and mRNA Transcript Response of Ovine 6-Phosphogluconate Dehydrogenase (6PGD) in Respect to Different Milk Yield
por: Trivizaki, Stamatina, et al.
Publicado: (2010)

Improving ethanol yield in acetate-reducing Saccharomyces cerevisiae by cofactor engineering of 6-phosphogluconate dehydrogenase and deletion of ALD6
por: Papapetridis, Ioannis, et al.
Publicado: (2016)

6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling
por: Lin, Ruiting, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of Phosphate Prodrugs of 4-Phospho-d -erythronohydroxamic Acid, an Inhibitor of 6-Phosphogluconate Dehydrogenase
por: Ruda, Gian Filippo, et al.
Publicado: (2007)

Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming
por: Bhanot, Haymanti, et al.
Publicado: (2017)

Role of 6‐phosphogluconate dehydrogenase enzyme 1 in growth and virulence of Toxoplasma gondii and development of attenuated live vaccine
por: Guo, Qinghong, et al.
Publicado: (2023)

Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia.
por: Jonas, S. K., et al.
Publicado: (1992)

Pathological crystal structures
por: Raymond, Kenneth N., et al.
Publicado: (2023)

Oxidative Pentose Phosphate Pathway Enzyme 6-Phosphogluconate Dehydrogenase Plays a Key Role in Breast Cancer Metabolism
por: Polat, Ibrahim H., et al.
Publicado: (2021)

6-Phosphogluconate dehydrogenase inhibition arrests growth and induces apoptosis in gastric cancer via AMPK activation and oxidative stress
por: Chen, Cheng, et al.
Publicado: (2023)

Inhibition of 6-Phosphogluconate Dehydrogenase Reverses Epirubicin Resistance Through Metabolic Reprograming in Triple-Negative Breast Cancer Cells
por: Xu, Jiali, et al.
Publicado: (2023)

Structure and function relationship of formate dehydrogenases: an overview of recent progress
por: Kobayashi, Ami, et al.
Publicado: (2023)

Why is interoperability between the two fields of chemical crystallography and protein crystallography so difficult?
por: Brink, Alice, et al.
Publicado: (2019)

Co-production of hydrogen and ethanol from glucose in Escherichia coli by activation of pentose-phosphate pathway through deletion of phosphoglucose isomerase (pgi) and overexpression of glucose-6-phosphate dehydrogenase (zwf) and 6-phosphogluconate dehydrogenase (gnd)
por: Sundara Sekar, Balaji, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ecq8u0uvf6rjhk0lndo1bdouc4