High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system

Cereblon (CRBN) is the substrate receptor of the CRL4(CRBN) E3 ubiquitin ligase and is a central player in targeted protein degradation. It is the target of the thalidomide-derived immunomodulatory drugs (IMiDs) and is one of the most widely employed receptors for proteolysis-targeting chimeras (PRO...

Descripción completa

Detalles Bibliográficos
Autores principales: Heim, Christopher, Hartmann, Marcus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900816/
https://www.ncbi.nlm.nih.gov/pubmed/35234143
http://dx.doi.org/10.1107/S2059798322000092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900816/
https://www.ncbi.nlm.nih.gov/pubmed/35234143
http://dx.doi.org/10.1107/S2059798322000092

Ejemplares similares