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Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cells

The recent COVID-19 pandemic poses a global health emergency. Cellular entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor-human angiotensin converting enzyme 2 (ACE2). Here, by using lentivirus based pseudotypes bearing spike protein, we demon...

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Detalles Bibliográficos
Autores principales:	Yang, Hang, Yuan, Huijun, Zhao, Xiaohui, Xun, Meng, Guo, Shangrui, Wang, Nan, Liu, Bing, Wang, Hongliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900885/ https://www.ncbi.nlm.nih.gov/pubmed/35272059 http://dx.doi.org/10.1016/j.virs.2022.03.003

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