Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L

Aberrant levels of cathepsin L (Cts L), a ubiquitously expressed endosomal cysteine protease, have been implicated in many diseases such as cancer and diabetes. Significantly, Cts L has been identified as a potential target for the treatment of COVID-19 due to its recently unveiled critical role in...

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Detalles Bibliográficos
Autores principales: Phan, Hoang Anh T., Giannakoulias, Sam G., Barrett, Taylor M., Liu, Chunxiao, Petersson, E. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901119/
https://www.ncbi.nlm.nih.gov/pubmed/35355937
http://dx.doi.org/10.1039/d1sc00785h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901119/
https://www.ncbi.nlm.nih.gov/pubmed/35355937
http://dx.doi.org/10.1039/d1sc00785h

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