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Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study
INTRODUCTION: Portal hypertension still represents an important health problem worldwide. In the search for knowledge regarding this syndrome, experimental studies with animal models have proven to be useful to point the direction to be taken in future randomized clinical trials. PURPOSE: To validat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901138/ https://www.ncbi.nlm.nih.gov/pubmed/35262597 http://dx.doi.org/10.1590/acb370103 |
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author | Maluf-Filho, Fauze Meyer, Alberto Martins, Pierre Pirchner Mathias Galvão, Flávio Henrique Ferreira D’Albuquerque, Luiz Augusto Carneiro |
author_facet | Maluf-Filho, Fauze Meyer, Alberto Martins, Pierre Pirchner Mathias Galvão, Flávio Henrique Ferreira D’Albuquerque, Luiz Augusto Carneiro |
author_sort | Maluf-Filho, Fauze |
collection | PubMed |
description | INTRODUCTION: Portal hypertension still represents an important health problem worldwide. In the search for knowledge regarding this syndrome, experimental studies with animal models have proven to be useful to point the direction to be taken in future randomized clinical trials. PURPOSE: To validate the experimental model of portal hypertension and esophagogastric varices in a medium-sized animal. METHODS: This study included five minipigs br1. Midline laparotomy with dissection of the portal vein and production of a calibrated stenosis of this vein was performed. Measurement of pressure in the portal venous and digestive endoscopic were performed before and five weeks after the production of a stenosis. RESULTS: All animals were 8 months old, average weight of 17 ± 2.5 kg. The mean pressure of the portal vein immediately before the partial ligation of the portal vein was 8.9 + 1.6 mm Hg, with 26.6 + 5.4 mm Hg in the second measurement five weeks later (p < 0.05). No gastroesophageal varices or hypertensive portal gastropathy were seen at endoscopy procedures in our sample at any time in the study. CONCLUSION: Portal vein ligation in minipigs has been validated in the production of portal hypertension, but not in the formation of esophageal varices. |
format | Online Article Text |
id | pubmed-8901138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-89011382022-03-17 Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study Maluf-Filho, Fauze Meyer, Alberto Martins, Pierre Pirchner Mathias Galvão, Flávio Henrique Ferreira D’Albuquerque, Luiz Augusto Carneiro Acta Cir Bras Original Article INTRODUCTION: Portal hypertension still represents an important health problem worldwide. In the search for knowledge regarding this syndrome, experimental studies with animal models have proven to be useful to point the direction to be taken in future randomized clinical trials. PURPOSE: To validate the experimental model of portal hypertension and esophagogastric varices in a medium-sized animal. METHODS: This study included five minipigs br1. Midline laparotomy with dissection of the portal vein and production of a calibrated stenosis of this vein was performed. Measurement of pressure in the portal venous and digestive endoscopic were performed before and five weeks after the production of a stenosis. RESULTS: All animals were 8 months old, average weight of 17 ± 2.5 kg. The mean pressure of the portal vein immediately before the partial ligation of the portal vein was 8.9 + 1.6 mm Hg, with 26.6 + 5.4 mm Hg in the second measurement five weeks later (p < 0.05). No gastroesophageal varices or hypertensive portal gastropathy were seen at endoscopy procedures in our sample at any time in the study. CONCLUSION: Portal vein ligation in minipigs has been validated in the production of portal hypertension, but not in the formation of esophageal varices. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2022-03-07 /pmc/articles/PMC8901138/ /pubmed/35262597 http://dx.doi.org/10.1590/acb370103 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Maluf-Filho, Fauze Meyer, Alberto Martins, Pierre Pirchner Mathias Galvão, Flávio Henrique Ferreira D’Albuquerque, Luiz Augusto Carneiro Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study |
title | Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study |
title_full | Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study |
title_fullStr | Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study |
title_full_unstemmed | Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study |
title_short | Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study |
title_sort | experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901138/ https://www.ncbi.nlm.nih.gov/pubmed/35262597 http://dx.doi.org/10.1590/acb370103 |
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