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Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis

INTRODUCTION: Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project....

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Autores principales: Jesson, Julie, Crichton, Siobhan, Quartagno, Matteo, Yotebieng, Marcel, Abrams, Elaine J., Chokephaibulkit, Kulkanya, Le Coeur, Sophie, Aké‐Assi, Marie‐Hélène, Patel, Kunjal, Pinto, Jorge, Paul, Mary, Vreeman, Rachel, Davies, Mary‐Ann, Ben‐Farhat, Jihane, Van Dyke, Russell, Judd, Ali, Mofenson, Lynne, Vicari, Marissa, Seage, George, Bekker, Linda‐Gail, Essajee, Shaffiq, Gibb, Diana, Penazzato, Martina, Collins, Intira Jeannie, Wools‐Kaloustian, Kara, Slogrove, Amy, Powis, Kate, Williams, Paige, Matshaba, Mogomotsi, Thahane, Lineo, Nyasulu, Phoebe, Lukhele, Bhekumusa, Mwita, Lumumba, Kekitiinwa‐Rukyalekere, Adeodata, Wanless, Sebastian, Goetghebuer, Tessa, Thorne, Claire, Warszawski, Josiane, Galli, Luisa, van Rossum, Annemarie M.C, Giaquinto, Carlo, Marczynska, Magdalena, Marques, Laura, Prata, Filipa, Ene, Luminita, Okhonskaya, Lyuba, Navarro, Marisa, Frick, Antoinette, Naver, Lars, Kahlert, Christian, Volokha, Alla, Chappell, Elizabeth, Pape, Jean William, Rouzier, Vanessa, Marcelin, Adias, Succi, Regina, Sohn, Annette H., Kariminia, Azar, Edmonds, Andrew, Lelo, Patricia, Lyamuya, Rita, Ogalo, Edith Apondi, Odhiambo, Francesca Akoth, Haas, Andreas D., Bolton, Carolyn, Muhairwe, Josephine, Tweya, Hannock, Sylla, Mariam, D'Almeida, Marceline, Renner, Lorna, Abzug, Mark J., Oleske, James, Purswani, Murli, Teasdale, Chloe, Nuwagaba‐Biribonwoha, Harriet, Goodall, Ruth, Leroy, Valériane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901148/
https://www.ncbi.nlm.nih.gov/pubmed/35255197
http://dx.doi.org/10.1002/jia2.25871
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author Jesson, Julie
Crichton, Siobhan
Quartagno, Matteo
Yotebieng, Marcel
Abrams, Elaine J.
Chokephaibulkit, Kulkanya
Le Coeur, Sophie
Aké‐Assi, Marie‐Hélène
Patel, Kunjal
Pinto, Jorge
Paul, Mary
Vreeman, Rachel
Davies, Mary‐Ann
Ben‐Farhat, Jihane
Van Dyke, Russell
Judd, Ali
Mofenson, Lynne
Vicari, Marissa
Seage, George
Bekker, Linda‐Gail
Essajee, Shaffiq
Gibb, Diana
Penazzato, Martina
Collins, Intira Jeannie
Wools‐Kaloustian, Kara
Slogrove, Amy
Powis, Kate
Williams, Paige
Matshaba, Mogomotsi
Thahane, Lineo
Nyasulu, Phoebe
Lukhele, Bhekumusa
Mwita, Lumumba
Kekitiinwa‐Rukyalekere, Adeodata
Wanless, Sebastian
Goetghebuer, Tessa
Thorne, Claire
Warszawski, Josiane
Galli, Luisa
van Rossum, Annemarie M.C
Giaquinto, Carlo
Marczynska, Magdalena
Marques, Laura
Prata, Filipa
Ene, Luminita
Okhonskaya, Lyuba
Navarro, Marisa
Frick, Antoinette
Naver, Lars
Kahlert, Christian
Volokha, Alla
Chappell, Elizabeth
Pape, Jean William
Rouzier, Vanessa
Marcelin, Adias
Succi, Regina
Sohn, Annette H.
Kariminia, Azar
Edmonds, Andrew
Lelo, Patricia
Lyamuya, Rita
Ogalo, Edith Apondi
Odhiambo, Francesca Akoth
Haas, Andreas D.
Bolton, Carolyn
Muhairwe, Josephine
Tweya, Hannock
Sylla, Mariam
D'Almeida, Marceline
Renner, Lorna
Abzug, Mark J.
Oleske, James
Purswani, Murli
Teasdale, Chloe
Nuwagaba‐Biribonwoha, Harriet
Goodall, Ruth
Leroy, Valériane
author_facet Jesson, Julie
Crichton, Siobhan
Quartagno, Matteo
Yotebieng, Marcel
Abrams, Elaine J.
Chokephaibulkit, Kulkanya
Le Coeur, Sophie
Aké‐Assi, Marie‐Hélène
Patel, Kunjal
Pinto, Jorge
Paul, Mary
Vreeman, Rachel
Davies, Mary‐Ann
Ben‐Farhat, Jihane
Van Dyke, Russell
Judd, Ali
Mofenson, Lynne
Vicari, Marissa
Seage, George
Bekker, Linda‐Gail
Essajee, Shaffiq
Gibb, Diana
Penazzato, Martina
Collins, Intira Jeannie
Wools‐Kaloustian, Kara
Slogrove, Amy
Powis, Kate
Williams, Paige
Matshaba, Mogomotsi
Thahane, Lineo
Nyasulu, Phoebe
Lukhele, Bhekumusa
Mwita, Lumumba
Kekitiinwa‐Rukyalekere, Adeodata
Wanless, Sebastian
Goetghebuer, Tessa
Thorne, Claire
Warszawski, Josiane
Galli, Luisa
van Rossum, Annemarie M.C
Giaquinto, Carlo
Marczynska, Magdalena
Marques, Laura
Prata, Filipa
Ene, Luminita
Okhonskaya, Lyuba
Navarro, Marisa
Frick, Antoinette
Naver, Lars
Kahlert, Christian
Volokha, Alla
Chappell, Elizabeth
Pape, Jean William
Rouzier, Vanessa
Marcelin, Adias
Succi, Regina
Sohn, Annette H.
Kariminia, Azar
Edmonds, Andrew
Lelo, Patricia
Lyamuya, Rita
Ogalo, Edith Apondi
Odhiambo, Francesca Akoth
Haas, Andreas D.
Bolton, Carolyn
Muhairwe, Josephine
Tweya, Hannock
Sylla, Mariam
D'Almeida, Marceline
Renner, Lorna
Abzug, Mark J.
Oleske, James
Purswani, Murli
Teasdale, Chloe
Nuwagaba‐Biribonwoha, Harriet
Goodall, Ruth
Leroy, Valériane
collection PubMed
description INTRODUCTION: Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project. METHODS: Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height‐for‐age Z‐scores (HAZ, stunting if <‐2 SD, WHO growth charts). Linear mixed‐effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex‐specific models with fractional polynomials were used to model non‐linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age. RESULTS: A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two‐thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to >7 years in sub‐Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia‐Pacific; 19% overall had CD4 counts <500 cells/mm(3). Across adolescence, higher HAZ was observed in females and among those in high‐income countries. APH with stunting at age 10 and those with late ART initiation (after age 5) had the largest HAZ gains during adolescence, but these gains were insufficient to catch‐up with non‐stunted, early ART‐treated adolescents. From age 10 to 16 years, mean CD4 counts declined from 768 to 607 cells/mm(3). This decline was observed across all regions, in males and females. CONCLUSIONS: Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood.
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spelling pubmed-89011482022-03-11 Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis Jesson, Julie Crichton, Siobhan Quartagno, Matteo Yotebieng, Marcel Abrams, Elaine J. Chokephaibulkit, Kulkanya Le Coeur, Sophie Aké‐Assi, Marie‐Hélène Patel, Kunjal Pinto, Jorge Paul, Mary Vreeman, Rachel Davies, Mary‐Ann Ben‐Farhat, Jihane Van Dyke, Russell Judd, Ali Mofenson, Lynne Vicari, Marissa Seage, George Bekker, Linda‐Gail Essajee, Shaffiq Gibb, Diana Penazzato, Martina Collins, Intira Jeannie Wools‐Kaloustian, Kara Slogrove, Amy Powis, Kate Williams, Paige Matshaba, Mogomotsi Thahane, Lineo Nyasulu, Phoebe Lukhele, Bhekumusa Mwita, Lumumba Kekitiinwa‐Rukyalekere, Adeodata Wanless, Sebastian Goetghebuer, Tessa Thorne, Claire Warszawski, Josiane Galli, Luisa van Rossum, Annemarie M.C Giaquinto, Carlo Marczynska, Magdalena Marques, Laura Prata, Filipa Ene, Luminita Okhonskaya, Lyuba Navarro, Marisa Frick, Antoinette Naver, Lars Kahlert, Christian Volokha, Alla Chappell, Elizabeth Pape, Jean William Rouzier, Vanessa Marcelin, Adias Succi, Regina Sohn, Annette H. Kariminia, Azar Edmonds, Andrew Lelo, Patricia Lyamuya, Rita Ogalo, Edith Apondi Odhiambo, Francesca Akoth Haas, Andreas D. Bolton, Carolyn Muhairwe, Josephine Tweya, Hannock Sylla, Mariam D'Almeida, Marceline Renner, Lorna Abzug, Mark J. Oleske, James Purswani, Murli Teasdale, Chloe Nuwagaba‐Biribonwoha, Harriet Goodall, Ruth Leroy, Valériane J Int AIDS Soc Research Articles INTRODUCTION: Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project. METHODS: Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height‐for‐age Z‐scores (HAZ, stunting if <‐2 SD, WHO growth charts). Linear mixed‐effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex‐specific models with fractional polynomials were used to model non‐linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age. RESULTS: A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two‐thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to >7 years in sub‐Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia‐Pacific; 19% overall had CD4 counts <500 cells/mm(3). Across adolescence, higher HAZ was observed in females and among those in high‐income countries. APH with stunting at age 10 and those with late ART initiation (after age 5) had the largest HAZ gains during adolescence, but these gains were insufficient to catch‐up with non‐stunted, early ART‐treated adolescents. From age 10 to 16 years, mean CD4 counts declined from 768 to 607 cells/mm(3). This decline was observed across all regions, in males and females. CONCLUSIONS: Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood. John Wiley and Sons Inc. 2022-03-07 /pmc/articles/PMC8901148/ /pubmed/35255197 http://dx.doi.org/10.1002/jia2.25871 Text en © 2022 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Jesson, Julie
Crichton, Siobhan
Quartagno, Matteo
Yotebieng, Marcel
Abrams, Elaine J.
Chokephaibulkit, Kulkanya
Le Coeur, Sophie
Aké‐Assi, Marie‐Hélène
Patel, Kunjal
Pinto, Jorge
Paul, Mary
Vreeman, Rachel
Davies, Mary‐Ann
Ben‐Farhat, Jihane
Van Dyke, Russell
Judd, Ali
Mofenson, Lynne
Vicari, Marissa
Seage, George
Bekker, Linda‐Gail
Essajee, Shaffiq
Gibb, Diana
Penazzato, Martina
Collins, Intira Jeannie
Wools‐Kaloustian, Kara
Slogrove, Amy
Powis, Kate
Williams, Paige
Matshaba, Mogomotsi
Thahane, Lineo
Nyasulu, Phoebe
Lukhele, Bhekumusa
Mwita, Lumumba
Kekitiinwa‐Rukyalekere, Adeodata
Wanless, Sebastian
Goetghebuer, Tessa
Thorne, Claire
Warszawski, Josiane
Galli, Luisa
van Rossum, Annemarie M.C
Giaquinto, Carlo
Marczynska, Magdalena
Marques, Laura
Prata, Filipa
Ene, Luminita
Okhonskaya, Lyuba
Navarro, Marisa
Frick, Antoinette
Naver, Lars
Kahlert, Christian
Volokha, Alla
Chappell, Elizabeth
Pape, Jean William
Rouzier, Vanessa
Marcelin, Adias
Succi, Regina
Sohn, Annette H.
Kariminia, Azar
Edmonds, Andrew
Lelo, Patricia
Lyamuya, Rita
Ogalo, Edith Apondi
Odhiambo, Francesca Akoth
Haas, Andreas D.
Bolton, Carolyn
Muhairwe, Josephine
Tweya, Hannock
Sylla, Mariam
D'Almeida, Marceline
Renner, Lorna
Abzug, Mark J.
Oleske, James
Purswani, Murli
Teasdale, Chloe
Nuwagaba‐Biribonwoha, Harriet
Goodall, Ruth
Leroy, Valériane
Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_full Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_fullStr Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_full_unstemmed Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_short Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_sort growth and cd4 patterns of adolescents living with perinatally acquired hiv worldwide, a cipher cohort collaboration analysis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901148/
https://www.ncbi.nlm.nih.gov/pubmed/35255197
http://dx.doi.org/10.1002/jia2.25871
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