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Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature

BACKGROUND: Perforation of Meckel Diverticulum (MD) is a rare cause of pneumoperitoneum in neonates. We hereby report six cases of perforation of MD in neonates, with addition of 53 cases from systematic review of the literature. A systematic review was performed using Mesh terms “Neonate, Meckel Di...

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Autores principales: Liaqat, Naeem, Mahomed, Anies, Nayyar, Sajid Iqbal, Akhtar, Nadeem, Ali, Sajjad, Haider, Naveed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901267/
https://www.ncbi.nlm.nih.gov/pubmed/35281619
http://dx.doi.org/10.1186/s43159-021-00154-z
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author Liaqat, Naeem
Mahomed, Anies
Nayyar, Sajid Iqbal
Akhtar, Nadeem
Ali, Sajjad
Haider, Naveed
author_facet Liaqat, Naeem
Mahomed, Anies
Nayyar, Sajid Iqbal
Akhtar, Nadeem
Ali, Sajjad
Haider, Naveed
author_sort Liaqat, Naeem
collection PubMed
description BACKGROUND: Perforation of Meckel Diverticulum (MD) is a rare cause of pneumoperitoneum in neonates. We hereby report six cases of perforation of MD in neonates, with addition of 53 cases from systematic review of the literature. A systematic review was performed using Mesh terms “Neonate, Meckel Diverticulum, Perforation, Pneumoperitoneum.” All reports of perforated MD in the English literature were identified. Details of our 6 cases were analyzed in similar fashion. RESULTS: A total of 3027 manuscripts were screened and 59 cases including 6 of our own were identified. The vast majority (78%) were female. Fifty patients (84.7%) presented in the newborn period. Half of the cases (52.5%) had associated anomalies and 13 neonates (22%) required oxygen supplementation including CPAP or ventilatory support before surgery. In 73% of the cases, a resection of gut was undertaken. Histopathological assessment in 44 cases (74.6%) revealed no ectopic gastric mucosa. Three cases demised prior to treatment. The outcome in the vast majority was excellent with 84.7% surviving and discharged well. CONCLUSION: Perforated MD is an unusual cause of a pneumoperitoneum in the newborns. Diagnosis is established at laparotomy and it rare to find ectopic mucosa histopathologically. The overall outcome is excellent.
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spelling pubmed-89012672022-03-08 Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature Liaqat, Naeem Mahomed, Anies Nayyar, Sajid Iqbal Akhtar, Nadeem Ali, Sajjad Haider, Naveed Ann Pediatr Surg Original Research BACKGROUND: Perforation of Meckel Diverticulum (MD) is a rare cause of pneumoperitoneum in neonates. We hereby report six cases of perforation of MD in neonates, with addition of 53 cases from systematic review of the literature. A systematic review was performed using Mesh terms “Neonate, Meckel Diverticulum, Perforation, Pneumoperitoneum.” All reports of perforated MD in the English literature were identified. Details of our 6 cases were analyzed in similar fashion. RESULTS: A total of 3027 manuscripts were screened and 59 cases including 6 of our own were identified. The vast majority (78%) were female. Fifty patients (84.7%) presented in the newborn period. Half of the cases (52.5%) had associated anomalies and 13 neonates (22%) required oxygen supplementation including CPAP or ventilatory support before surgery. In 73% of the cases, a resection of gut was undertaken. Histopathological assessment in 44 cases (74.6%) revealed no ectopic gastric mucosa. Three cases demised prior to treatment. The outcome in the vast majority was excellent with 84.7% surviving and discharged well. CONCLUSION: Perforated MD is an unusual cause of a pneumoperitoneum in the newborns. Diagnosis is established at laparotomy and it rare to find ectopic mucosa histopathologically. The overall outcome is excellent. Springer Berlin Heidelberg 2022-03-08 2022 /pmc/articles/PMC8901267/ /pubmed/35281619 http://dx.doi.org/10.1186/s43159-021-00154-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Research
Liaqat, Naeem
Mahomed, Anies
Nayyar, Sajid Iqbal
Akhtar, Nadeem
Ali, Sajjad
Haider, Naveed
Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature
title Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature
title_full Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature
title_fullStr Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature
title_full_unstemmed Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature
title_short Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature
title_sort perforated meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901267/
https://www.ncbi.nlm.nih.gov/pubmed/35281619
http://dx.doi.org/10.1186/s43159-021-00154-z
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