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Hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients

BACKGROUND: Congenital heart disease CHD is a significant cause of mortality and morbidity in children worldwide. Patients with congenital heart disease may develop hematological problems, including thrombocytopenia and neutropenia. In addition, several studies indicate the higher frailty of patient...

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Autores principales: Mohammadi, Hanieh, Mohammadpour Ahranjani, Behzad, Aghaei Moghadam, Ehsan, Kompani, Farzad, Mirbeyk, Mona, Rezaei, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901268/
https://www.ncbi.nlm.nih.gov/pubmed/37521840
http://dx.doi.org/10.1186/s43042-022-00262-4
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author Mohammadi, Hanieh
Mohammadpour Ahranjani, Behzad
Aghaei Moghadam, Ehsan
Kompani, Farzad
Mirbeyk, Mona
Rezaei, Nima
author_facet Mohammadi, Hanieh
Mohammadpour Ahranjani, Behzad
Aghaei Moghadam, Ehsan
Kompani, Farzad
Mirbeyk, Mona
Rezaei, Nima
author_sort Mohammadi, Hanieh
collection PubMed
description BACKGROUND: Congenital heart disease CHD is a significant cause of mortality and morbidity in children worldwide. Patients with congenital heart disease may develop hematological problems, including thrombocytopenia and neutropenia. In addition, several studies indicate the higher frailty of patients with CHDs to infections and malignancies. Nevertheless, the mechanisms of immune system changes in these patients have remained in the shadow of uncertainty. Moreover, very few studies have worked on cytopenia in CHD. This study has assessed the frequency of thrombocytopenia, neutropenia, lymphopenia, and anemia in pediatric patients with acyanotic congenital heart disease ACHD prior to open-heart surgery. METHODS: This cross-sectional study was handled in the Pediatric Cardiology Clinic, Tehran University of Medical Sciences, during pre-operation visits from 2014 till 2019. Two hundred forty-eight children and adolescents with acyanotic congenital heart disease before open-heart surgery met the criteria to enter the study. RESULTS: A total of 191 (76.7%) patients with Ventricular Septal Defects (VSD), 37 (14.85%) patients with Atrial Septal Defects (ASD), and 20 (8.11%) patients with Patent Ductus Arteriosus (PDA) were enrolled in this study. The median age was 23.87 months. Thrombocytopenia and neutropenia were found, respectively, in 3 (1.2) and 23 (9.2%) patients. Hemoglobin level and lymphocyte count were significantly lower in patients with neutropenia than patients with normal neutrophil count (P value = 0.024 and P value = 0.000). Significant positive correlations were found between neutropenia and anemia. There were no correlations between neutrophil count and Platelets. Also, anemia was found in 48 patients (19.3%). The study also found a statistically significant correlation between the co-existence of VSD and neutropenia in the patients (P value = 0.000). CONCLUSION: Although most were mildly neutropenic, there was a significant correlation between neutropenia and Ventricular Septal Defect compared to PDA and ASD groups. Regarding the importance of neutropenia to affect the prognosis of congenital heart defects in infections, it is important to consider further studies on the status of immune system function in these patients.
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spelling pubmed-89012682022-03-08 Hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients Mohammadi, Hanieh Mohammadpour Ahranjani, Behzad Aghaei Moghadam, Ehsan Kompani, Farzad Mirbeyk, Mona Rezaei, Nima Egypt J Med Hum Genet Research BACKGROUND: Congenital heart disease CHD is a significant cause of mortality and morbidity in children worldwide. Patients with congenital heart disease may develop hematological problems, including thrombocytopenia and neutropenia. In addition, several studies indicate the higher frailty of patients with CHDs to infections and malignancies. Nevertheless, the mechanisms of immune system changes in these patients have remained in the shadow of uncertainty. Moreover, very few studies have worked on cytopenia in CHD. This study has assessed the frequency of thrombocytopenia, neutropenia, lymphopenia, and anemia in pediatric patients with acyanotic congenital heart disease ACHD prior to open-heart surgery. METHODS: This cross-sectional study was handled in the Pediatric Cardiology Clinic, Tehran University of Medical Sciences, during pre-operation visits from 2014 till 2019. Two hundred forty-eight children and adolescents with acyanotic congenital heart disease before open-heart surgery met the criteria to enter the study. RESULTS: A total of 191 (76.7%) patients with Ventricular Septal Defects (VSD), 37 (14.85%) patients with Atrial Septal Defects (ASD), and 20 (8.11%) patients with Patent Ductus Arteriosus (PDA) were enrolled in this study. The median age was 23.87 months. Thrombocytopenia and neutropenia were found, respectively, in 3 (1.2) and 23 (9.2%) patients. Hemoglobin level and lymphocyte count were significantly lower in patients with neutropenia than patients with normal neutrophil count (P value = 0.024 and P value = 0.000). Significant positive correlations were found between neutropenia and anemia. There were no correlations between neutrophil count and Platelets. Also, anemia was found in 48 patients (19.3%). The study also found a statistically significant correlation between the co-existence of VSD and neutropenia in the patients (P value = 0.000). CONCLUSION: Although most were mildly neutropenic, there was a significant correlation between neutropenia and Ventricular Septal Defect compared to PDA and ASD groups. Regarding the importance of neutropenia to affect the prognosis of congenital heart defects in infections, it is important to consider further studies on the status of immune system function in these patients. Springer Berlin Heidelberg 2022-03-08 2022 /pmc/articles/PMC8901268/ /pubmed/37521840 http://dx.doi.org/10.1186/s43042-022-00262-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Mohammadi, Hanieh
Mohammadpour Ahranjani, Behzad
Aghaei Moghadam, Ehsan
Kompani, Farzad
Mirbeyk, Mona
Rezaei, Nima
Hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients
title Hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients
title_full Hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients
title_fullStr Hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients
title_full_unstemmed Hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients
title_short Hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients
title_sort hematological indices in pediatric patients with acyanotic congenital heart disease: a cross-sectional study of 248 patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901268/
https://www.ncbi.nlm.nih.gov/pubmed/37521840
http://dx.doi.org/10.1186/s43042-022-00262-4
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