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The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery
BACKGROUND: Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity due to the defective hepatic metabolism of vitami...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901332/ https://www.ncbi.nlm.nih.gov/pubmed/35265372 http://dx.doi.org/10.1155/2022/7319742 |
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author | Jamialahmadi, Tannaz Nematy, Mohsen Abdalla, Mohammed Jangjoo, Ali Goshayeshi, Ladan Kroh, Matthew Moallem, Seyed Adel Abbasifard, Mitra Sathyapalan, Thozhukat Sahebkar, Amirhossein |
author_facet | Jamialahmadi, Tannaz Nematy, Mohsen Abdalla, Mohammed Jangjoo, Ali Goshayeshi, Ladan Kroh, Matthew Moallem, Seyed Adel Abbasifard, Mitra Sathyapalan, Thozhukat Sahebkar, Amirhossein |
author_sort | Jamialahmadi, Tannaz |
collection | PubMed |
description | BACKGROUND: Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity due to the defective hepatic metabolism of vitamin D. Bariatric surgery is performed to help patients with BMI>40 kg/m(2) to effectively lose weight, particularly in patients with obesity who are afflicted with complications such as NAFLD/NASH. OBJECTIVE: This study aimed to evaluate the PTH level as a predictor of hepatic function in individuals with morbid obesity who have undergone bariatric surgery. METHODS: Ninety subjects with morbid obesity referred for Roux en-Y gastric bypass surgery were recruited. After IRB approval, demographic profiles, anthropometric factors, liver biopsy, and laboratory tests were obtained. The two-dimensional shear wave elastography (2D-SWE) technique was applied to assess hepatic stiffness. RESULTS: A significant reduction occurred six months after bariatric surgery in the anthropometric indices (p < 0.001), hepatic elasticity (p=0.002), alanine aminotransferase (p < 0.001), serum alkaline phosphatase (p < 0.001), gamma-glutamyl transpeptidase (GGT) (p < 0.001), and nonalcoholic fatty liver disease fibrosis score (NFS) (p < 0.001). Serum PTH concentration was not predictive of postsurgical liver fibrosis and steatosis at six months but could predict weight loss success rate. No significant alteration in serum PTH levels was observed between presurgical vs. postsurgical time points. CONCLUSION: A significant reduction was observed in the anthropometric parameters, liver enzymes, and hepatic elasticity after bariatric surgery. No significant effect was found on PTH levels. |
format | Online Article Text |
id | pubmed-8901332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89013322022-03-08 The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery Jamialahmadi, Tannaz Nematy, Mohsen Abdalla, Mohammed Jangjoo, Ali Goshayeshi, Ladan Kroh, Matthew Moallem, Seyed Adel Abbasifard, Mitra Sathyapalan, Thozhukat Sahebkar, Amirhossein J Nutr Metab Research Article BACKGROUND: Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity due to the defective hepatic metabolism of vitamin D. Bariatric surgery is performed to help patients with BMI>40 kg/m(2) to effectively lose weight, particularly in patients with obesity who are afflicted with complications such as NAFLD/NASH. OBJECTIVE: This study aimed to evaluate the PTH level as a predictor of hepatic function in individuals with morbid obesity who have undergone bariatric surgery. METHODS: Ninety subjects with morbid obesity referred for Roux en-Y gastric bypass surgery were recruited. After IRB approval, demographic profiles, anthropometric factors, liver biopsy, and laboratory tests were obtained. The two-dimensional shear wave elastography (2D-SWE) technique was applied to assess hepatic stiffness. RESULTS: A significant reduction occurred six months after bariatric surgery in the anthropometric indices (p < 0.001), hepatic elasticity (p=0.002), alanine aminotransferase (p < 0.001), serum alkaline phosphatase (p < 0.001), gamma-glutamyl transpeptidase (GGT) (p < 0.001), and nonalcoholic fatty liver disease fibrosis score (NFS) (p < 0.001). Serum PTH concentration was not predictive of postsurgical liver fibrosis and steatosis at six months but could predict weight loss success rate. No significant alteration in serum PTH levels was observed between presurgical vs. postsurgical time points. CONCLUSION: A significant reduction was observed in the anthropometric parameters, liver enzymes, and hepatic elasticity after bariatric surgery. No significant effect was found on PTH levels. Hindawi 2022-02-28 /pmc/articles/PMC8901332/ /pubmed/35265372 http://dx.doi.org/10.1155/2022/7319742 Text en Copyright © 2022 Tannaz Jamialahmadi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jamialahmadi, Tannaz Nematy, Mohsen Abdalla, Mohammed Jangjoo, Ali Goshayeshi, Ladan Kroh, Matthew Moallem, Seyed Adel Abbasifard, Mitra Sathyapalan, Thozhukat Sahebkar, Amirhossein The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery |
title | The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery |
title_full | The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery |
title_fullStr | The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery |
title_full_unstemmed | The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery |
title_short | The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery |
title_sort | predictive role of parathyroid hormone for nonalcoholic fatty liver disease following bariatric surgery |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901332/ https://www.ncbi.nlm.nih.gov/pubmed/35265372 http://dx.doi.org/10.1155/2022/7319742 |
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