An Overview of SARS-CoV-2 Molecular Diagnostics in Europe

The COVID-19 pandemic has led to the rapid development of a plethora of molecular diagnostic assays with real-time polymerase chain reaction (RT-PCR) at the forefront. In this review, we will discuss the history and utility of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) molecular di...

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Detalles Bibliográficos
Autores principales: Davies, Emma, Farooq, Hamzah Z., Brown, Benjamin, Tilston, Peter, McEwan, Ashley, Birtles, Andrew, O’Hara, Robert William, Ahmad, Shazaad, Machin, Nicholas, Hesketh, Louise, Guiver, Malcolm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901364/
https://www.ncbi.nlm.nih.gov/pubmed/35636820
http://dx.doi.org/10.1016/j.cll.2022.02.005
Descripción
Sumario:The COVID-19 pandemic has led to the rapid development of a plethora of molecular diagnostic assays with real-time polymerase chain reaction (RT-PCR) at the forefront. In this review, we will discuss the history and utility of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) molecular diagnostics and the associated current and future regulatory process in Europe. We will assess the performance characteristics of a range of the most common SARS-CoV-2 molecular tests currently used in Europe with a focus on as rapid molecular platforms, stand-alone RT-PCR kits, the role of low-throughput and high-throughput end-to-end testing platforms, and the rapidly evolving field of SARS-CoV-2 variant of concern identification.

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