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8C-like cells capture the human zygotic genome activation program in vitro

The activation of the embryonic genome marks the first major wave of transcription in the developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell embryos in humans is crucial for development. Here, we report the discovery of human 8-cell-like cells (8CLCs) among naive...

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Detalles Bibliográficos
Autores principales: Taubenschmid-Stowers, Jasmin, Rostovskaya, Maria, Santos, Fátima, Ljung, Sebastian, Argelaguet, Ricard, Krueger, Felix, Nichols, Jennifer, Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901440/
https://www.ncbi.nlm.nih.gov/pubmed/35216671
http://dx.doi.org/10.1016/j.stem.2022.01.014