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On the dynamic and even reversible nature of Leigh syndrome: Lessons from human imaging and mouse models
Leigh syndrome (LS) is a neurodegenerative disease characterized by bilaterally symmetric brainstem or basal ganglia lesions. More than 80 genes, largely impacting mitochondrial energy metabolism, can underlie LS, and no approved medicines exist. Described 70 years ago, LS was initially diagnosed by...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901530/ https://www.ncbi.nlm.nih.gov/pubmed/34656053 http://dx.doi.org/10.1016/j.conb.2021.09.006 |