Cargando…

Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study

We investigated the association between lung function and atrial fibrillation (AF) in 21,349 adults without AF aged ≥ 40 years who underwent spirometry. The study participants were enrolled from the Korean National Health and Nutritional Examination Survey between 2008 and 2016. The primary outcome...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Su Nam, Ko, Seung-Hyun, Her, Sung-Ho, Han, Kyungdo, Moon, Donggyu, Kim, Sung Kyoung, Yoo, Ki-Dong, Ahn, Yu-Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901639/
https://www.ncbi.nlm.nih.gov/pubmed/35256653
http://dx.doi.org/10.1038/s41598-022-07534-4
_version_ 1784664409383108608
author Lee, Su Nam
Ko, Seung-Hyun
Her, Sung-Ho
Han, Kyungdo
Moon, Donggyu
Kim, Sung Kyoung
Yoo, Ki-Dong
Ahn, Yu-Bae
author_facet Lee, Su Nam
Ko, Seung-Hyun
Her, Sung-Ho
Han, Kyungdo
Moon, Donggyu
Kim, Sung Kyoung
Yoo, Ki-Dong
Ahn, Yu-Bae
author_sort Lee, Su Nam
collection PubMed
description We investigated the association between lung function and atrial fibrillation (AF) in 21,349 adults without AF aged ≥ 40 years who underwent spirometry. The study participants were enrolled from the Korean National Health and Nutritional Examination Survey between 2008 and 2016. The primary outcome was new-onset non-valvular AF identified from the National Health Insurance Service database. During the median follow-up of 6.5 years, 2.15% of participants developed new-onset AF. The incidence rate of AF per 1000 person-years was inversely related to the forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC), and FEV(1)/FVC quartile. After adjustment for multiple variables, the AF risk in the lowest FEV(1) quartile was 1.64-fold higher than that in the highest quartile (hazard ratio (HR) 1.64 (95% confidence interval (CI) 1.26–2.12) for lowest FEV(1) quartile). The lowest quartile of FVC had 1.56-fold higher AF risk than the highest quartile (HR 1.56 (95% CI 1.18–2.08) for lowest FVC quartile). Although the lowest FEV(1)/FVC quartile was associated with an increased risk of AF in the unadjusted model, this increased risk was not statistically significant in the multivariable analysis. Compared to those with normal lung function, participants with restrictive or obstructive lung function had 1.49 and 1.42-fold higher AF risks, respectively. In this large nationwide cohort study, both obstructive and restrictive patterns of reduced lung function were significantly associated with increased AF risk.
format Online
Article
Text
id pubmed-8901639
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-89016392022-03-08 Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study Lee, Su Nam Ko, Seung-Hyun Her, Sung-Ho Han, Kyungdo Moon, Donggyu Kim, Sung Kyoung Yoo, Ki-Dong Ahn, Yu-Bae Sci Rep Article We investigated the association between lung function and atrial fibrillation (AF) in 21,349 adults without AF aged ≥ 40 years who underwent spirometry. The study participants were enrolled from the Korean National Health and Nutritional Examination Survey between 2008 and 2016. The primary outcome was new-onset non-valvular AF identified from the National Health Insurance Service database. During the median follow-up of 6.5 years, 2.15% of participants developed new-onset AF. The incidence rate of AF per 1000 person-years was inversely related to the forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC), and FEV(1)/FVC quartile. After adjustment for multiple variables, the AF risk in the lowest FEV(1) quartile was 1.64-fold higher than that in the highest quartile (hazard ratio (HR) 1.64 (95% confidence interval (CI) 1.26–2.12) for lowest FEV(1) quartile). The lowest quartile of FVC had 1.56-fold higher AF risk than the highest quartile (HR 1.56 (95% CI 1.18–2.08) for lowest FVC quartile). Although the lowest FEV(1)/FVC quartile was associated with an increased risk of AF in the unadjusted model, this increased risk was not statistically significant in the multivariable analysis. Compared to those with normal lung function, participants with restrictive or obstructive lung function had 1.49 and 1.42-fold higher AF risks, respectively. In this large nationwide cohort study, both obstructive and restrictive patterns of reduced lung function were significantly associated with increased AF risk. Nature Publishing Group UK 2022-03-07 /pmc/articles/PMC8901639/ /pubmed/35256653 http://dx.doi.org/10.1038/s41598-022-07534-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lee, Su Nam
Ko, Seung-Hyun
Her, Sung-Ho
Han, Kyungdo
Moon, Donggyu
Kim, Sung Kyoung
Yoo, Ki-Dong
Ahn, Yu-Bae
Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
title Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
title_full Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
title_fullStr Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
title_full_unstemmed Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
title_short Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
title_sort association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901639/
https://www.ncbi.nlm.nih.gov/pubmed/35256653
http://dx.doi.org/10.1038/s41598-022-07534-4
work_keys_str_mv AT leesunam associationbetweenlungfunctionandtheriskofatrialfibrillationinanationwidepopulationcohortstudy
AT koseunghyun associationbetweenlungfunctionandtheriskofatrialfibrillationinanationwidepopulationcohortstudy
AT hersungho associationbetweenlungfunctionandtheriskofatrialfibrillationinanationwidepopulationcohortstudy
AT hankyungdo associationbetweenlungfunctionandtheriskofatrialfibrillationinanationwidepopulationcohortstudy
AT moondonggyu associationbetweenlungfunctionandtheriskofatrialfibrillationinanationwidepopulationcohortstudy
AT kimsungkyoung associationbetweenlungfunctionandtheriskofatrialfibrillationinanationwidepopulationcohortstudy
AT yookidong associationbetweenlungfunctionandtheriskofatrialfibrillationinanationwidepopulationcohortstudy
AT ahnyubae associationbetweenlungfunctionandtheriskofatrialfibrillationinanationwidepopulationcohortstudy