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Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
We investigated the association between lung function and atrial fibrillation (AF) in 21,349 adults without AF aged ≥ 40 years who underwent spirometry. The study participants were enrolled from the Korean National Health and Nutritional Examination Survey between 2008 and 2016. The primary outcome...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901639/ https://www.ncbi.nlm.nih.gov/pubmed/35256653 http://dx.doi.org/10.1038/s41598-022-07534-4 |
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author | Lee, Su Nam Ko, Seung-Hyun Her, Sung-Ho Han, Kyungdo Moon, Donggyu Kim, Sung Kyoung Yoo, Ki-Dong Ahn, Yu-Bae |
author_facet | Lee, Su Nam Ko, Seung-Hyun Her, Sung-Ho Han, Kyungdo Moon, Donggyu Kim, Sung Kyoung Yoo, Ki-Dong Ahn, Yu-Bae |
author_sort | Lee, Su Nam |
collection | PubMed |
description | We investigated the association between lung function and atrial fibrillation (AF) in 21,349 adults without AF aged ≥ 40 years who underwent spirometry. The study participants were enrolled from the Korean National Health and Nutritional Examination Survey between 2008 and 2016. The primary outcome was new-onset non-valvular AF identified from the National Health Insurance Service database. During the median follow-up of 6.5 years, 2.15% of participants developed new-onset AF. The incidence rate of AF per 1000 person-years was inversely related to the forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC), and FEV(1)/FVC quartile. After adjustment for multiple variables, the AF risk in the lowest FEV(1) quartile was 1.64-fold higher than that in the highest quartile (hazard ratio (HR) 1.64 (95% confidence interval (CI) 1.26–2.12) for lowest FEV(1) quartile). The lowest quartile of FVC had 1.56-fold higher AF risk than the highest quartile (HR 1.56 (95% CI 1.18–2.08) for lowest FVC quartile). Although the lowest FEV(1)/FVC quartile was associated with an increased risk of AF in the unadjusted model, this increased risk was not statistically significant in the multivariable analysis. Compared to those with normal lung function, participants with restrictive or obstructive lung function had 1.49 and 1.42-fold higher AF risks, respectively. In this large nationwide cohort study, both obstructive and restrictive patterns of reduced lung function were significantly associated with increased AF risk. |
format | Online Article Text |
id | pubmed-8901639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89016392022-03-08 Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study Lee, Su Nam Ko, Seung-Hyun Her, Sung-Ho Han, Kyungdo Moon, Donggyu Kim, Sung Kyoung Yoo, Ki-Dong Ahn, Yu-Bae Sci Rep Article We investigated the association between lung function and atrial fibrillation (AF) in 21,349 adults without AF aged ≥ 40 years who underwent spirometry. The study participants were enrolled from the Korean National Health and Nutritional Examination Survey between 2008 and 2016. The primary outcome was new-onset non-valvular AF identified from the National Health Insurance Service database. During the median follow-up of 6.5 years, 2.15% of participants developed new-onset AF. The incidence rate of AF per 1000 person-years was inversely related to the forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC), and FEV(1)/FVC quartile. After adjustment for multiple variables, the AF risk in the lowest FEV(1) quartile was 1.64-fold higher than that in the highest quartile (hazard ratio (HR) 1.64 (95% confidence interval (CI) 1.26–2.12) for lowest FEV(1) quartile). The lowest quartile of FVC had 1.56-fold higher AF risk than the highest quartile (HR 1.56 (95% CI 1.18–2.08) for lowest FVC quartile). Although the lowest FEV(1)/FVC quartile was associated with an increased risk of AF in the unadjusted model, this increased risk was not statistically significant in the multivariable analysis. Compared to those with normal lung function, participants with restrictive or obstructive lung function had 1.49 and 1.42-fold higher AF risks, respectively. In this large nationwide cohort study, both obstructive and restrictive patterns of reduced lung function were significantly associated with increased AF risk. Nature Publishing Group UK 2022-03-07 /pmc/articles/PMC8901639/ /pubmed/35256653 http://dx.doi.org/10.1038/s41598-022-07534-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lee, Su Nam Ko, Seung-Hyun Her, Sung-Ho Han, Kyungdo Moon, Donggyu Kim, Sung Kyoung Yoo, Ki-Dong Ahn, Yu-Bae Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study |
title | Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study |
title_full | Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study |
title_fullStr | Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study |
title_full_unstemmed | Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study |
title_short | Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study |
title_sort | association between lung function and the risk of atrial fibrillation in a nationwide population cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901639/ https://www.ncbi.nlm.nih.gov/pubmed/35256653 http://dx.doi.org/10.1038/s41598-022-07534-4 |
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