ATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway

The present study was performed to explore whether and how impaired autophagy could modulate calcium/calmodulin-dependent protein kinase II (CAMKII)-regulated necrosis in the pathogenesis of acute pancreatitis (AP). Wistar rats and AR42J cells were used for AP modeling. When indicated, genetic regul...

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Detalles Bibliográficos
Autores principales: Ji, Liang, Wang, Zhi-hong, Zhang, Yu-hua, Zhou, Yi, Tang, De-sheng, Yan, Chang-sheng, Ma, Jia-min, Fang, Kun, Gao, Lei, Ren, Nian-sheng, Cheng, Long, Guo, Xiao-yu, Sun, Bei, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901675/
https://www.ncbi.nlm.nih.gov/pubmed/35256590
http://dx.doi.org/10.1038/s41419-022-04657-4

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