Cargando…
An exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis
A previous randomised controlled trial showed that an anti-inflammatory diet (AID) significantly reduced gingival inflammation despite constant plaque values. This exploratory study investigated the role of serum fatty acids in relation to the observed clinical effects. Therefore, data of thirty par...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901712/ https://www.ncbi.nlm.nih.gov/pubmed/35256737 http://dx.doi.org/10.1038/s41598-022-07989-5 |
_version_ | 1784664429087948800 |
---|---|
author | Kruse, Anne B. Gärtner, Maximilian Vach, Kirstin Grueninger, Dirk Peikert, Stefanie A. Ratka-Krüger, Petra Tennert, Christian Woelber, Johan P. |
author_facet | Kruse, Anne B. Gärtner, Maximilian Vach, Kirstin Grueninger, Dirk Peikert, Stefanie A. Ratka-Krüger, Petra Tennert, Christian Woelber, Johan P. |
author_sort | Kruse, Anne B. |
collection | PubMed |
description | A previous randomised controlled trial showed that an anti-inflammatory diet (AID) significantly reduced gingival inflammation despite constant plaque values. This exploratory study investigated the role of serum fatty acids in relation to the observed clinical effects. Therefore, data of thirty participants with gingivitis, following either a pro-inflammatory dietary pattern (PID) rich in saturated fat, omega 6 fatty acids, and refined carbohydrates or an AID for 4 weeks, were correlated with corresponding serum samples for a variety of fatty acids. Changes in the fatty acid profile and effects on clinical periodontal parameters were analysed. Results showed that the polyunsatured:saturated fatty acids ratio (PUFA:SFA ratio) and nervonic acid level were significantly higher in the AID group than in the PID group at the end of the study. Significant intragroup differences were seen only in the AID group. Diverse fatty acids showed heterogeneous relations to clinical parameters. This study demonstrated that the serum fatty acid profile was not fundamentally associated with the clinical gingivitis-lowering effects of an AID in short-term, although some fatty acids showed individual relations to clinical parameters with respect to inflammation. Hence, short-term effects of dietary therapy on gingivitis may be rather based on carbohydrate-related effects and/or micronutrients. |
format | Online Article Text |
id | pubmed-8901712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89017122022-03-08 An exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis Kruse, Anne B. Gärtner, Maximilian Vach, Kirstin Grueninger, Dirk Peikert, Stefanie A. Ratka-Krüger, Petra Tennert, Christian Woelber, Johan P. Sci Rep Article A previous randomised controlled trial showed that an anti-inflammatory diet (AID) significantly reduced gingival inflammation despite constant plaque values. This exploratory study investigated the role of serum fatty acids in relation to the observed clinical effects. Therefore, data of thirty participants with gingivitis, following either a pro-inflammatory dietary pattern (PID) rich in saturated fat, omega 6 fatty acids, and refined carbohydrates or an AID for 4 weeks, were correlated with corresponding serum samples for a variety of fatty acids. Changes in the fatty acid profile and effects on clinical periodontal parameters were analysed. Results showed that the polyunsatured:saturated fatty acids ratio (PUFA:SFA ratio) and nervonic acid level were significantly higher in the AID group than in the PID group at the end of the study. Significant intragroup differences were seen only in the AID group. Diverse fatty acids showed heterogeneous relations to clinical parameters. This study demonstrated that the serum fatty acid profile was not fundamentally associated with the clinical gingivitis-lowering effects of an AID in short-term, although some fatty acids showed individual relations to clinical parameters with respect to inflammation. Hence, short-term effects of dietary therapy on gingivitis may be rather based on carbohydrate-related effects and/or micronutrients. Nature Publishing Group UK 2022-03-07 /pmc/articles/PMC8901712/ /pubmed/35256737 http://dx.doi.org/10.1038/s41598-022-07989-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kruse, Anne B. Gärtner, Maximilian Vach, Kirstin Grueninger, Dirk Peikert, Stefanie A. Ratka-Krüger, Petra Tennert, Christian Woelber, Johan P. An exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis |
title | An exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis |
title_full | An exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis |
title_fullStr | An exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis |
title_full_unstemmed | An exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis |
title_short | An exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis |
title_sort | exploratory study on the role of serum fatty acids in the short-term dietary therapy of gingivitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901712/ https://www.ncbi.nlm.nih.gov/pubmed/35256737 http://dx.doi.org/10.1038/s41598-022-07989-5 |
work_keys_str_mv | AT kruseanneb anexploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT gartnermaximilian anexploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT vachkirstin anexploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT grueningerdirk anexploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT peikertstefaniea anexploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT ratkakrugerpetra anexploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT tennertchristian anexploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT woelberjohanp anexploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT kruseanneb exploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT gartnermaximilian exploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT vachkirstin exploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT grueningerdirk exploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT peikertstefaniea exploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT ratkakrugerpetra exploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT tennertchristian exploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis AT woelberjohanp exploratorystudyontheroleofserumfattyacidsintheshorttermdietarytherapyofgingivitis |