Antimicrobial activity of supramolecular salts of gallium(III) and proflavine and the intriguing case of a trioxalate complex

The use of the gallium oxalate complex [Ga(ox)(3)](3−) as a building block in the formation of a drug-drug salt with the antimicrobial agent proflavine (PF) as its proflavinium cation (HPF(+)), namely [HPF](3)[Ga(ox)(3)]·4H(2)O, is reported together with the preparation of the potassium salt K(3)[Ga...

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Autores principales: Guerrini, Marzia, d’Agostino, Simone, Grepioni, Fabrizia, Braga, Dario, Lekhan, Andrii, Turner, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901752/
https://www.ncbi.nlm.nih.gov/pubmed/35256712
http://dx.doi.org/10.1038/s41598-022-07813-0
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author Guerrini, Marzia
d’Agostino, Simone
Grepioni, Fabrizia
Braga, Dario
Lekhan, Andrii
Turner, Raymond J.
author_facet Guerrini, Marzia
d’Agostino, Simone
Grepioni, Fabrizia
Braga, Dario
Lekhan, Andrii
Turner, Raymond J.
author_sort Guerrini, Marzia
collection PubMed
description The use of the gallium oxalate complex [Ga(ox)(3)](3−) as a building block in the formation of a drug-drug salt with the antimicrobial agent proflavine (PF) as its proflavinium cation (HPF(+)), namely [HPF](3)[Ga(ox)(3)]·4H(2)O, is reported together with the preparation of the potassium salt K(3)[Ga(ox)(3)] and the novel dimeric gallium(III) salt K(4)[Ga(2)(ox)(4)(μ-OH)(2)]·2H(2)O. All compounds have been characterized by solid state methods, and their performance as antimicrobial agents has been evaluated by disk diffusion assay against the bacteria strains Pseudomonas aeruginosa ATCC27853, Staphylococcus aureus ATCC25923, and Escherichia coli ATCC25922. While the [HPF](3)[Ga(ox)(3)]·4H(2)O drug-drug salt is effective against all three strains, the gallium oxalate salt K(3)[Ga(ox)(3)] showed impressive selectivity towards P. aeruginosa, with little to no antimicrobial activity against the other two organisms. This work presents novel breakthroughs towards Ga based antimicrobial agents.
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spelling pubmed-89017522022-03-08 Antimicrobial activity of supramolecular salts of gallium(III) and proflavine and the intriguing case of a trioxalate complex Guerrini, Marzia d’Agostino, Simone Grepioni, Fabrizia Braga, Dario Lekhan, Andrii Turner, Raymond J. Sci Rep Article The use of the gallium oxalate complex [Ga(ox)(3)](3−) as a building block in the formation of a drug-drug salt with the antimicrobial agent proflavine (PF) as its proflavinium cation (HPF(+)), namely [HPF](3)[Ga(ox)(3)]·4H(2)O, is reported together with the preparation of the potassium salt K(3)[Ga(ox)(3)] and the novel dimeric gallium(III) salt K(4)[Ga(2)(ox)(4)(μ-OH)(2)]·2H(2)O. All compounds have been characterized by solid state methods, and their performance as antimicrobial agents has been evaluated by disk diffusion assay against the bacteria strains Pseudomonas aeruginosa ATCC27853, Staphylococcus aureus ATCC25923, and Escherichia coli ATCC25922. While the [HPF](3)[Ga(ox)(3)]·4H(2)O drug-drug salt is effective against all three strains, the gallium oxalate salt K(3)[Ga(ox)(3)] showed impressive selectivity towards P. aeruginosa, with little to no antimicrobial activity against the other two organisms. This work presents novel breakthroughs towards Ga based antimicrobial agents. Nature Publishing Group UK 2022-03-07 /pmc/articles/PMC8901752/ /pubmed/35256712 http://dx.doi.org/10.1038/s41598-022-07813-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Guerrini, Marzia
d’Agostino, Simone
Grepioni, Fabrizia
Braga, Dario
Lekhan, Andrii
Turner, Raymond J.
Antimicrobial activity of supramolecular salts of gallium(III) and proflavine and the intriguing case of a trioxalate complex
title Antimicrobial activity of supramolecular salts of gallium(III) and proflavine and the intriguing case of a trioxalate complex
title_full Antimicrobial activity of supramolecular salts of gallium(III) and proflavine and the intriguing case of a trioxalate complex
title_fullStr Antimicrobial activity of supramolecular salts of gallium(III) and proflavine and the intriguing case of a trioxalate complex
title_full_unstemmed Antimicrobial activity of supramolecular salts of gallium(III) and proflavine and the intriguing case of a trioxalate complex
title_short Antimicrobial activity of supramolecular salts of gallium(III) and proflavine and the intriguing case of a trioxalate complex
title_sort antimicrobial activity of supramolecular salts of gallium(iii) and proflavine and the intriguing case of a trioxalate complex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901752/
https://www.ncbi.nlm.nih.gov/pubmed/35256712
http://dx.doi.org/10.1038/s41598-022-07813-0
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