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The influence of the pH on the incorporation of caffeic acid into biomimetic membranes and cancer cells

Caffeic acid (CA) is a phenolic compound synthesized by all plant species. It constitutes the main hydroxycinnamic acid found in human diet and presents a variety of beneficial effects including anticancer activity. Current data suggests essential role of the interplay between anticancer drugs and t...

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Autores principales: Naumowicz, Monika, Kusaczuk, Magdalena, Zając, Marcin, Jabłońska-Trypuć, Agata, Mikłosz, Agnieszka, Gál, Miroslav, Worobiczuk, Mateusz, Kotyńska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901767/
https://www.ncbi.nlm.nih.gov/pubmed/35256690
http://dx.doi.org/10.1038/s41598-022-07700-8
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author Naumowicz, Monika
Kusaczuk, Magdalena
Zając, Marcin
Jabłońska-Trypuć, Agata
Mikłosz, Agnieszka
Gál, Miroslav
Worobiczuk, Mateusz
Kotyńska, Joanna
author_facet Naumowicz, Monika
Kusaczuk, Magdalena
Zając, Marcin
Jabłońska-Trypuć, Agata
Mikłosz, Agnieszka
Gál, Miroslav
Worobiczuk, Mateusz
Kotyńska, Joanna
author_sort Naumowicz, Monika
collection PubMed
description Caffeic acid (CA) is a phenolic compound synthesized by all plant species. It constitutes the main hydroxycinnamic acid found in human diet and presents a variety of beneficial effects including anticancer activity. Current data suggests essential role of the interplay between anticancer drugs and the cell membrane. Given this, biophysical interactions between CA and cancer cells or biomimetic membranes were investigated. Glioblastoma cell line U118MG and colorectal adenocarcinoma cell line DLD-1, as well as lipid bilayers and liposomes, were used as in vitro models. Electrophoretic light scattering was used to assess the effect of CA on the surface charge of cancer cells and liposomal membranes. Electrochemical impedance spectroscopy was chosen to evaluate CA-dependent modulatory effect on the electrical capacitance and electrical resistance of the bilayers. Our results suggest that CA fulfills physicochemical criteria determining drug-like properties of chemical compounds, and may serve as a potential cytostatic agent in cancer treatment.
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spelling pubmed-89017672022-03-08 The influence of the pH on the incorporation of caffeic acid into biomimetic membranes and cancer cells Naumowicz, Monika Kusaczuk, Magdalena Zając, Marcin Jabłońska-Trypuć, Agata Mikłosz, Agnieszka Gál, Miroslav Worobiczuk, Mateusz Kotyńska, Joanna Sci Rep Article Caffeic acid (CA) is a phenolic compound synthesized by all plant species. It constitutes the main hydroxycinnamic acid found in human diet and presents a variety of beneficial effects including anticancer activity. Current data suggests essential role of the interplay between anticancer drugs and the cell membrane. Given this, biophysical interactions between CA and cancer cells or biomimetic membranes were investigated. Glioblastoma cell line U118MG and colorectal adenocarcinoma cell line DLD-1, as well as lipid bilayers and liposomes, were used as in vitro models. Electrophoretic light scattering was used to assess the effect of CA on the surface charge of cancer cells and liposomal membranes. Electrochemical impedance spectroscopy was chosen to evaluate CA-dependent modulatory effect on the electrical capacitance and electrical resistance of the bilayers. Our results suggest that CA fulfills physicochemical criteria determining drug-like properties of chemical compounds, and may serve as a potential cytostatic agent in cancer treatment. Nature Publishing Group UK 2022-03-07 /pmc/articles/PMC8901767/ /pubmed/35256690 http://dx.doi.org/10.1038/s41598-022-07700-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Naumowicz, Monika
Kusaczuk, Magdalena
Zając, Marcin
Jabłońska-Trypuć, Agata
Mikłosz, Agnieszka
Gál, Miroslav
Worobiczuk, Mateusz
Kotyńska, Joanna
The influence of the pH on the incorporation of caffeic acid into biomimetic membranes and cancer cells
title The influence of the pH on the incorporation of caffeic acid into biomimetic membranes and cancer cells
title_full The influence of the pH on the incorporation of caffeic acid into biomimetic membranes and cancer cells
title_fullStr The influence of the pH on the incorporation of caffeic acid into biomimetic membranes and cancer cells
title_full_unstemmed The influence of the pH on the incorporation of caffeic acid into biomimetic membranes and cancer cells
title_short The influence of the pH on the incorporation of caffeic acid into biomimetic membranes and cancer cells
title_sort influence of the ph on the incorporation of caffeic acid into biomimetic membranes and cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901767/
https://www.ncbi.nlm.nih.gov/pubmed/35256690
http://dx.doi.org/10.1038/s41598-022-07700-8
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